A series of derivatives of 2,4- and 2,5-thiazolyl- or oxazolylbenzenesulphonamides has been prepared and evaluated as potential MMP inhibitors. The thiazole 15b have been found to exhibit MMP-2 and MMP-9 inhibitions higher than reference compounds GI 129471 and CGS 27023A.
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New heteroarylbenzenesulphonamides as matrix metalloproteinase inhibitors.
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Groupe de Recherches sur l'Inhibition de la Prolifération Cellulaire UPRES EA 2692, Equipe de Chimie Organique, Université des Sciences et Technologies de Lille, F-59655 Villeneuve d'Ascq, France.
A series of derivatives of 2,4- and 2,5-thiazolyl- or oxazolylbenzenesulphonamides has been prepared and evaluated as potential MMP inhibitors. The thiazole 15b have been found to exhibit MMP-2 and MMP-9 inhibitions higher than reference compounds GI 129471 and CGS 27023A.
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