A robust method for the solid phase synthesis of a series of selective caspase-3 peptide inhibitors is described. The inhibitors can be obtained after cleavage from the solid support without further purification.
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http://dx.doi.org/10.1016/j.bmc.2004.01.007 | DOI Listing |
J Mater Chem A Mater
December 2024
Faculty of Applied Sciences, Delft University of Technology 2629 JB Delft The Netherlands
Solid-state batteries currently receive ample attention due to their potential to outperform lithium-ion batteries in terms of energy density when featuring next-generation anodes such as lithium metal or silicon. One key remaining challenge is identifying solid electrolytes that combine high ionic conductivity with stability in contact with the highly reducing potentials of next-generation anodes. Fully reduced electrolytes, based on irreducible anions, offer a promising solution by avoiding electrolyte decomposition altogether.
View Article and Find Full Text PDFFood Sci Nutr
December 2024
Center of High Altitude Medicine West China Hospital, Sichuan University Chengdu China.
Solid Phase Microextraction-Gas Chromatography Triple Quadrupole Mass Spectrometry (SPME-GC-TQ/MS) was optimized and validated to specifically analyze aldehydes and furans after drying by conventional as well as modern pre-drying technique i.e. pulsed electric field (PEF).
View Article and Find Full Text PDFSe Pu
January 2025
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
17-Estradiol (E2) is a natural steroidal estrogen essential for a variety of physiological functions in organisms. However, external E2, which is renowned for its potent biological effects, is also considered to be an endocrine-disrupting compound (EDC) capable of disturbing the normal operation of the endocrine system, even at nanogram-per-liter (ng/L) concentrations. Studies have revealed that medical and livestock wastewater can be contaminated with E2, which poses potential risks to human health.
View Article and Find Full Text PDFSe Pu
January 2025
School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Chlorinated coumarins, which are as cytotoxic as highly toxic halobenzoquinones toward CHO-K1 cells, have recently been identified as disinfection byproducts in drinking water disinfection processes. Therefore, detecting coumarins in water samples collected at various stages from drinking water treatment plants helps assess the formation of chlorinated coumarins in drinking water. Hence, a simple, rapid, accurate, and sensitive method for quantifying coumarins in water samples is required.
View Article and Find Full Text PDFPhthalates (PAEs) are endocrine-disrupting chemicals that are widely present in everyday life and enter the human body through various pathways. The release of PAEs into the environment through pathways that include leaching, evaporation, abrasion, and the use of personal care products exposes humans to PAEs via ingestion, inhalation, and dermal absorption. Pregnant women, as a particularly vulnerable population, risk adverse newborn growth and development when exposed to PAEs.
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