To achieve an optimum drug delivery such as targeting or controlled release utilizing bioconjugation with polymeric modifier, the conjugate between drugs and polymeric modifiers must be designed to show desirable pharmacokinetic characteristics in vivo. In this study, we assessed the biopharmaceutical properties of various nonionic water-soluble polymers as polymeric drug carriers. Polyvinylpyrrolidone (PVP) showed the longest mean resident time (MRT) after i.v. injection of all nonionic polymers with the same molecular size. In fact, tumor necrosis factor-alpha (TNF-alpha) bioconjugated with PVP (PVP-TNF-alpha) circulated longer than TNF-alpha bioconjugated with polyethylene glycol (PEG-TNF-alpha) with the same molecular size. Each nonionic polymeric modifier showed a different tissue distribution. Dextran was accumulated in the spleen and liver. Polydimethylacrylamide (PDAAm) tended to distribute in the kidney. However, PVP showed the minimum volume of tissue distribution. These results suggested that PVP is the most suitable polymeric modifier for prolonging the circulation lifetime of a drug and localizing the conjugated drug in blood.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.biomaterials.2003.10.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The preparation of 3D-printed self-healing hydrogels composed of carboxymethyl chitosan and oxidized dextran via stereolithography for biomedical applications.
Int J Biol Macromol
December 2024
National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathum Thani 12120, Thailand.
This study presents a new approach for fabricating 3D-printed self-healing hydrogels via light-assisted 3D printing, utilizing Schiff-base and covalent bonding formations resulting from the reaction between amine and aldehyde functional groups alongside the photopolymerization of methacrylate groups. Two distinct polymers, carboxymethyl chitosan (CMCs) and dextran, were first modified to yield methacrylate-modified carboxymethyl chitosan (CMCs-MA) and oxidized dextran (OD). The structural modifications of these polymers were confirmed using spectroscopic techniques, including H NMR and FTIR analyses.
View Article and Find Full Text PDFBiomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy.
Sci Rep
December 2024
Department of Clinical Laboratory, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, 212002, Jiangsu, China.
Tumor heterogeneity, immune-suppressive microenvironment and the precise killing of tumor cells by drugs are important factors affecting tumor treatment. In this study, we developed environment-responsive drug delivery system (FM@IQ/PST&ZIF-8/DOX) based on ZIF-8 for tumor photothermal/immunotherapy/chemotherapy synergistic therapy. The prepared FM@IQ/PST&ZIF-8/DOX nanoplatfrom not only has highly drug loading capacity for chemotherapeutic drug-doxorubicin, but also erythrocyte membrance modified on their surface can endow their immunity-escaping property and prolong their blood circulation time.
View Article and Find Full Text PDFA novel electrochemical immunosensor for the ultrasensitive detection of vascular endothelial growth factor based on MB@Cu-MOFs/MWCNTs composite.
Mikrochim Acta
December 2024
School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
A novel proposal is introduced with an unlabeled electrochemical immunosensor for the detection of tumor broad-spectrum biomarker vascular endothelial growth factor (VEGF165) Copper-based metal organic frameworks (Cu MOFs)-carbon nanotubes (MWCNTs) were employed as its substrates, functionalized with methylene blue (MB) for signal enhancement. Cu-MOFs-MWCNTs nanocomposites were synthesized successfully via a solvothermal method and were then deposited on the surface of a glassy carbon electrode (GCE), with the addition of methylene blue to amplify the signal. Due to the expansive specific surface area provided by the carbon nanotubes and the amino groups facilitated by the metal-organic framework nanomaterials, the anti-VEGF165 monoclonal antibody was immobilized on the electrochemical immunosensor through covalent bonding, which could bind specifically to VEGF165, thereby causing a detectable change in the current.
View Article and Find Full Text PDFElectrochemical polymerized DL-phenylalanine modified carbon nanotube sensor for the selective and sensitive determination of caffeic acid with riboflavin.
Sci Rep
December 2024
Department of Civil, Environmental and Mechanical Engineering, University of Trento, Via Mesiano, 77, 38123, Trento, Italy.
In this study, DL-phenylalanine modified with a multiwall carbon nanotube paste electrode is used as advanced electrochemical sensor for analysing of 0.1 mM caffeic acid (CFA) with simultaneous detection of riboflavin (RFN). The developed sensors include electrochemically polymerized DL-phenylalanine (DL-PA) modified multiwall carbon nanotube paste electrode [DL-PAMMCNTPE] and bare multiwall carbon nanotube paste electrode [BMCNTPE].
View Article and Find Full Text PDFSynthesis, characterization, experimental design and process analysis of heavy metals adsorption on a wheat straw based amidoximated bioadsorbent.
Sci Rep
December 2024
Faculty of Chemical Engineering, Urmia University of Technology, Urmia, 17165‑57166, Iran.
In this research, 3-(trimethoxysilyl)propyl methacrylate (MPS) silane agent was applied to modify the extracted wheat straw (WS) cellulose as a natural biopolymer. Polyacrylonitrile (PAN) was attached to the MPS-modified WS (MPS-WS) via in-situ polymerization to form PAN-WS biocomposite. AO-WS amidoximated biocomposite adsorbent was synthesized through amidoxime reaction and the effects of different parameters including agitation speed, metal ion concentration, and adsorbent dosage on its efficiency of Pb(II) removal were investigated using the Taguchi experimental design method.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!