We report a case of Budd-Chiari syndrome revealing a polycythemia vera and complicated by heparin-induced thrombocytopenia. A surgical porto-caval shunt was inserted with danaparoid as anticoagulant during the peri-operative period. The doses of danaparoid were as follows: a continuous intravenous infusion of 200 U/h with a target between 0.5 et 0.8 U/ml antifactor Xa activity during the preoperative period, followed by 100 U/h with a target of 0.3 U/ml during the peroperative period; an increase in doses of danaparoid to 150 and 200 U/h with a target above 0.5 U/ml was used during the postoperative period. This case report is a rare situation of hypercoagulable state, in a surgical context, treated with danaparoid.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.annfar.2003.10.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ion Pair Chromatography for Endogenous Metabolite LC-MS Analysis in Tissue Samples Following HGH Resolution Untargeted Acquisition.
Methods Mol Biol
January 2025
Bioscience, Research and Early Development, Oncology, AstraZeneca, Cambridge, Cambridgeshire, UK.
A protocol for the preparation of tissue extracts for the targeted analysis ca. 150 polar metabolites, including those involved in central carbon metabolism, is described, using a reversed phase ion pair U(H)PLC-MS method. Data collection enabled in high-resolution mass spectrometry detection provides highly specific and sensitive acquisition of metabolic intermediates with wide range physicochemical properties and pathway coverage.
View Article and Find Full Text PDFDetection of Bacterial Infections and Malaria among Blood Culture-Negative Samples of Hospitalized Febrile Patients from a Tertiary Hospital in Ethiopia.
Am J Trop Med Hyg
January 2025
Hirsch Institute of Tropical Medicine, Asella, Ethiopia.
Article Synopsis
- Febrile illnesses are a major health issue in sub-Saharan Africa, often leading to inadequate treatment due to limited diagnostic resources and a wide range of possible pathogens.
- This study focused on evaluating a multiplex polymerase chain reaction (PCR) method for diagnosing febrile diseases in patients at a hospital in Central Ethiopia over two years, testing samples from 511 patients.
- The results showed that while pathogens were detected in only 6.3% of the samples, including Plasmodium and Borrelia, the use of multiplex PCR can still enhance diagnostic capabilities and inform better clinical management in settings with limited resources.
Pulmonary hypertension in adults with congenital heart defects (ACHDs) in light of the 2022 ESC PAH guidelines-part II: supportive therapy, special situations (pregnancy, contraception, non-cardiac surgery), targeted pharmacotherapy, organ transplantation, special management (shunt lesion, left ventricular disease, univentricular hearts), interventions, intensive care, ACHD follow-up, future perspective.
Cardiovasc Diagn Ther
October 2024
Department of Pediatric Cardiology, University Hospital for Pediatrics and Adolescent Medicine Ulm, Ulm, Germany.
Article Synopsis
- * The revised 2022 guidelines from the European Society of Cardiology/European Respiratory Society address PH but only briefly consider the needs of adults with congenital heart defects.
- * The article aims to enhance understanding of ACHD management by exploring various aspects such as diagnostics, specialized therapies, and unique circumstances, thereby addressing gaps in current guidelines.
Pulmonary hypertension in adults with congenital heart defects (ACHDs)-in light of the 2022 ESC PAH guidelines-part I: definition, epidemiology, classification, diagnostics, genetics, risk stratification and follow-up, gender aspects.
Cardiovasc Diagn Ther
October 2024
Department of Pediatric Cardiology, University Hospital for Pediatrics and Adolescent Medicine Ulm, Ulm, Germany.
Article Synopsis
- * The 2022 guidelines by the European Society of Cardiology and the European Respiratory Society address PH management but only briefly cover the specific needs of adults with congenital heart defects.
- * This article reviews various aspects of ACHDs and PH, including their epidemiology, risk factors, and management challenges, aiming to enhance awareness and care strategies for this patient population.
Comparative Cardiovascular Effectiveness of Empagliflozin Versus Dapagliflozin in Adults With Treated Type 2 Diabetes: A Target Trial Emulation.
Circulation
October 2024
Departments of Clinical Epidemiology (K.B., U.H.-J., D.H.C., L.P., R.W.T., M.S.), Aarhus University Hospital, Denmark.
Background: Empagliflozin and dapagliflozin have proven cardiovascular benefits in people with type 2 diabetes at high cardiovascular risk, but their comparative effectiveness is unknown.
Methods: This study used nationwide, population-based Danish health registries to emulate a hypothetical target trial comparing empagliflozin versus dapagliflozin initiation, in addition to standard care, among people with treated type 2 diabetes from 2014 through 2020. The outcome was a composite of myocardial infarction, ischemic stroke, heart failure (HF), or cardiovascular death (major adverse cardiovascular event).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!