In order to experience a method for the choice in Public Health, a list of the problems in occupational health in Florence has been characterized one, using for the definition of the priorities a "Minnesota Department of Health's Community Health Services Planning Manual--Guidelines for Local Public Health Agencies: CHS Plan Cycle 2002-2003". The following priorities problems of health are emerged in order of: exposure to chemistries in agricultural workers, fatal and serious injures among construction and agricultural workers, musculoskeletal disorders by biomechanical overload of the upper limbs, hearing loss. For everyone of they, has been indicated a possible strategy.
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Manganese exposure induces parkinsonism-like symptoms by Serpina3n-TFEB-v/p-ATPase signaling mediated lysosomal dysfunction.
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January 2025
Department of Environmental Medicine, School of Medicine, Chongqing University, Chongqing, China.
Manganese (Mn) is a neurotoxin that has been etiologically linked to the development of neurodegenerative diseases in the case of overexposure. It is widely accepted that overexposure to Mn leads to manganism, which has clinical symptoms similar to Parkinson's disease (PD), and is referred to as parkinsonism. Astrocytes have been reported to scavenge and degrade extracellular α-synuclein (α-Syn) in the brain.
View Article and Find Full Text PDFA physiologically based pharmacokinetic (PBPK) model describing the kinetics of a commercial mixture α-, β-, and γ-hexabromocyclododecane exposure in mice.
Arch Toxicol
January 2025
Scientist Emeritus, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Hexabromocyclododecane (HBCD) is a brominated flame retardant, that is added, but not chemically bonded, to consumer products. HBCD is sold as a commercial-grade HBCD mixture containing three major stereoisomers: alpha (α), beta (β), and gamma (γ), with relative amounts of 12% for α-HBCD, 6% for β-HBCD, and 82% for γ-HBCD. HBCDs are widely measured in the environment and in biological matrices.
View Article and Find Full Text PDFIdentification of distinct pesticide poisoning patterns in Brazil: a cross-sectional cluster analysis of epidemiological data.
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Department of Quantitative Methods, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Purpose: This study aimed to identify distinct patterns of pesticide poisoning in Brazil through the cluster analysis of epidemiological data from 2011 to 2019.
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Occupational Rhinoconjunctivitis Induced by Flaxseed: Identification of Novel Allergenic Proteins From Cupin, Chaperonin, and Enzyme Families.
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Section of Occupational Medicine, Respiratory Diseases and Toxicology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
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About the Authors Dawna Rutherford, PhD, RN, adjunct clinical instructor, Salem State University, Salem, Massachusetts, is with Staff Nurse/Traveler RN Network, Nome, Alaska. Gordon Lee Gillespie, PhD, DNP, RN, was professor, College of Nursing, University of Cincinnati, Cincinnati, Ohio, when this study was conducted. He is currently chief program officer, National League for Nursing. Scott Bresler, PhD, was clinical director, Division of Forensic Psychiatry, University of Cincinnati College of Medicine, when this study was conducted. Kimberly Johnson, PhD, RN, CEN, and Carolyn R. Smith, PhD, RN, CNE, are associate professors, College of Nursing, University of Cincinnati. This study was funded by an award to Dr. Rutherford from the National Institute for Occupational Safety and Health through the Pilot Research Project Training Program of the University of Cincinnati Education and Research Center Grant #T42OH008432. For more information, contact Dr. Gillespie at
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