Aims: To test the hypothesis that apnoea of infancy (AOI) is due to a deficit in chemoreception.
Methods: Tests were performed on 112 infants: 43 healthy control infants, 28 infants with periodic breathing or central apnoea (PBCA), and 41 infants with obstructive apnoea (OA) on overnight polysomnography. Chemoreceptor responses to hypercapnia (4% and 6% CO2 in air) for 6-8 minutes and hyperoxia (100% O2) for 60 seconds were expressed in terms of response strength and reaction time. Age at birth (gestational week 37-41) and age at test (2-34 postnatal weeks) were comparable across groups (median, min-max value). A total of 70 CO2 and 71 O2 tests were analysed.
Results: The strongest and fastest CO2 responders were control infants: their median increase in ventilation was 291%/kPaCO2 and their reaction time 16 breaths. In infants with PBCA and OA, the increase in ventilation was 41% and 130%/kPaCO2, and reaction time 64 and 54 breaths, respectively. There was a significant negative correlation between CO2 response strength and response time. In response to hyperoxia there was a comparable decrease in ventilation in all infants (12-20%), but a significantly longer response time in infants with apnoea (20 v 12 breaths). There was no correlation between the response strength and response time to O2 and CO2.
Conclusion: An inappropriate central control of respiration is an important mechanism in the pathogenesis of apnoea of infancy.
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| http://dx.doi.org/10.1136/adc.2003.030957 | DOI Listing |
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