This article reviews the causes of childhood obesity and suggests different approaches to treatment and prevention.
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| http://dx.doi.org/10.7748/ns2004.01.18.20.47.c3537 | DOI Listing |
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Chronic kidney disease.
Nat Rev Dis Primers
January 2025
Division of Nephrology, Department of Medicine IV, Hospital of the Ludwig-Maximilians University, Munich, Germany.
Chronic kidney disease (CKD) is defined by persistent abnormalities of kidney function or structure that have consequences for the health. A progressive decline of excretory kidney function has effects on body homeostasis. CKD is tightly associated with accelerated cardiovascular disease and severe infections, and with premature death.
View Article and Find Full Text PDFThe importance of thiamine availability in the thermogenic competency of human adipocytes.
Mol Cell Endocrinol
January 2025
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, H-4032, Debrecen, Hungary. Electronic address:
Brown and beige adipocytes express uncoupling protein-1 (UCP1), which is located in the inner mitochondrial membrane and facilitates the dissipation of excess energy as heat. The activation of thermogenic adipocytes is a potential therapeutic target for treating type 2 diabetes mellitus, obesity, and related co-morbidities. Therefore, identifying novel approaches to stimulate the function of these adipocytes is crucial for advancing therapeutic strategies.
View Article and Find Full Text PDFAlström syndrome: A rare cause of dilated cardiomyopathy in five Chinese children.
Gene
January 2025
Department of Cardiology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China. Electronic address:
Backgroud: The ALMS1 gene is predominantly localized to cilia, particularly in the photoreceptor cells of the retina, auditory neurons, kidneys, and other ciliated structures. Pathogenic mutations in this gene cause Alstrom syndrome (AS), which is characterized by dilated cardiomyopathy, retinal degeneration, neurodeafness, and centripetal obesity. However, the genetic mechanism of the ALMS1 gene remains unclear.
View Article and Find Full Text PDFThe Association Between Physical Activity and Markers of Obesity in Children Living With Obesity.
Pediatr Exerc Sci
January 2025
INTEGRA-Integrative Physiology, Health, and Performance Research Group, Federal University of Rio Grande do Norte, Natal, RN,Brazil.
Purpose: The purpose of this study is to describe the association between the volume and intensity of accelerometer-assessed physical activity (PA) and markers of obesity.
Method: Forty-seven children (20 girls) took part in this investigation. Children wore accelerometers on their nondominant wrists for 7 days.
Precision nutrition-based interventions for the management of obesity in children and adolescents up to the age of 19 years.
Cochrane Database Syst Rev
January 2025
Cornell Joan Klein Jacobs Center for Precision Nutrition and Health, Cornell University, Ithaca, NY, USA.
Background: Precision nutrition-based methods develop tailored interventions and/or recommendations accounting for determinants of intra- and inter-individual variation in response to the same diet, compared to current 'one-size-fits-all' population-level approaches. Determinants may include genetics, current dietary habits and eating patterns, circadian rhythms, health status, gut microbiome, socioeconomic and psychosocial characteristics, and physical activity. In this systematic review, we examined the evidence base for the effect of interventions based on precision nutrition approaches on overweight and obesity in children and adolescents to help inform future research and global guidelines.
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