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Initiation of Anticoagulants During the COVID-19 Pandemic in Sweden: An Interrupted Time Series Analysis.
Basic Clin Pharmacol Toxicol
February 2025
Pharmacoepidemiology, Department of Pharmacy, Uppsala University, Uppsala, Sweden.
The COVID-19 pandemic may have increased anticoagulant initiation due to the thrombogenic nature of the disease or decreased due to the societal impact of the pandemic. We aimed to study the effect of the COVID-19 pandemic on initiation of anticoagulants in Sweden. We conducted a single interrupted time series analysis on the monthly cumulative incidence of nonvitamin K antagonist oral anticoagulants (NOAC), warfarin, or heparins, before and after March 2020, using SCIFI-PEARL dataset.
View Article and Find Full Text PDFTime-resolved fluorescence measurements of dissolved organic matter (DOM) as a function of environmental parameters in estuarine waters.
Environ Sci Pollut Res Int
January 2025
Department of Chemistry, College of Science and Engineering, Western Washington University, 516 High Street, Bellingham, WA, 98229, USA.
Fluorescent lifetimes of dissolved organic matter (DOM) and associated physicochemical parameters were measured over 14 months in an estuary in Southern California, USA. Measurements were made on 77 samples from sites near the inlet, mid-estuary, and outlet to maximize the range of physicochemical variables. Time-resolved fluorescence data were well fit to a triexponential model with an intermediate lifetime component (τ: 1 to 5 ns), a long lifetime component (τ: 2 to 15 ns), and a short lifetime component (τ: < 1 ns).
View Article and Find Full Text PDFBody composition is associated with changes in health-related quality of life in patients with knee and/or hip osteoarthritis.
RMD Open
January 2025
CIC, Epidémiologie Clinique, INSERM, Nancy University Hospital Center, Nancy, Grand Est, France.
Objective: The objective of this study was to analyse the association between body composition and changes in health-related quality of life (HRQoL) of patients followed for hip and knee osteoarthritis (OA).
Methods: Longitudinal data from the Knee and Hip OsteoArthritis Long-term Assessments (KHOALA) cohort, a multicentre cohort of 878 patients with symptomatic knee and/or hip OA, were used. The main outcome criteria were changes in patient-reported outcomes measures, the Study Short Form-36 (physical functioning, pain, mental health and vitality) and the OsteoArthritis Knee and Hip Quality Of Life (OAKHQOL)(physical activity, pain and mental health).
Defining Textbook Outcomes for Minimally Invasive Surgical Resection of Small Gastrointestinal Stromal Tumors (GIST) of the Stomach.
Ann Surg Oncol
January 2025
Department of Surgery, University of California San Diego School of Medicine, San Diego, CA, USA.
Background: Textbook outcome (TO) has been utilized to assess the quality of surgical care. This study aimed to define TO rates for minimally invasive gastric gastrointestinal stromal tumor (GIST) resections in a bi-institutional cohort.
Methods: Patients with gastric GIST (≤ 5 cm) who underwent laparoscopic or robotic resection (January 2014 to January 2024) were retrospectively identified from two GIST centers.
Trends and cost structure of drug-based secondary prevention of ischemic strokes.
Neurol Res Pract
January 2025
Goethe University Frankfurt, University Hospital, Department of Neurology, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany.
Background: Advances in secondary stroke prevention, including direct oral anticoagulants (DOACs), dual antiplatelet therapies (DAPT), and cardiovascular risk management, have changed costs over the past decade. This study aimed to evaluate annual treatment costs and trends in drug-based secondary prophylaxis after ischemic strokes.
Methods: Annual treatment costs were evaluated using the net costs per defined daily dosage (DDD) of discharge medications for ischemic stroke patients treated in 2020 at the University Hospital Frankfurt, Germany.
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