AI Article Synopsis
- High mobility group (HMG) proteins are crucial chromosomal proteins that help form complex structures within DNA.
- Mammalian HMG proteins are categorized into three families: HMGB, HMGN, and HMGA, based on their specific sequences.
- Drosophila melanogaster and Chironomus tentans have been studied extensively, revealing three key nonhistone HMG proteins, with two from the HMGB family and one from the HMGA family, which may influence higher order nucleoprotein structures and gene regulation.
Article Abstract
High mobility group (HMG) proteins are an abundant class of chromosomal proteins facilitate assembly of higher order structures. The mammalian HMG proteins have been grouped into three distinct families on the basis of their characteristic functional sequence: the HMGB, the HMGN, and the HMGA family. The HMG proteins of Drosophila melanogaster and Chironomus tentans are the best characterized dipteran insect HMG proteins. Three abundant members of this group of nonhistone proteins were detected in those insects. Two of them belong to the HMGB family and one to the HMGA family. The possible relatedness of these proteins to the formation of higher order nucleoprotein structures and their possible role in the regulation of transcription is discussed.
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| http://dx.doi.org/10.1023/b:bigi.0000006030.05308.04 | DOI Listing |
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