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Adaptable Method for Dynamic Planning of 3D Spatial Wireframes Extrusion with Neural Networks and Robotic Automation.
3D Print Addit Manuf
August 2022
Department of Architecture, School of Architecture, Tsinghua University, Beijing, China.
3D extrusion of spatial wireframe provides an alternate method for additive manufacture, which holds a significant advantage over the typical layering printing method in terms of material and time efficiency. However, the complexity of the structure and unsupported printing process are major challenges for path planning of extrusion process. This article presents a method to plan and control the path for extruding 3D spatial wireframes by synthesizing dynamic material behaviors such as heat deformation, plasticity, and bending, during the curing process as active contributors to the printed form.
View Article and Find Full Text PDFPayment options: An analysis of 6 years of payment plan data and potential implications for for-profit clinics, non-profit veterinary providers, and funders to access to care initiatives.
Front Vet Sci
August 2022
Independent Researcher, Bedford, OH, United States.
Analyzing a dataset of payment plans disassociated with traditional credit scoring, this research, for the first time, offers insights into the mitigation of cash flow and credit ineligibility challenges in access to veterinary care. Specifically, this paper explores financial fragility among pet families and whether payment options offer substantial bridges in access to care challenges for veterinarians and clients. Researchers introduce a veterinary care multiplier to estimate the potential increase in veterinary care that may be provided by for-profit and non-profit clinics from additional payment options.
View Article and Find Full Text PDFThe E3 Ligase TRIM4 Facilitates SET Ubiquitin-Mediated Degradation to Enhance ER-α Action in Breast Cancer.
Adv Sci (Weinh)
September 2022
Department of Breast Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.
Estrogen receptor alpha (ER-α) action is critical for hormone-dependent breast cancer, and ER-α dysregulation can lead to the emergence of resistance to endocrine therapy. Here, it is found that TRIM4 is downregulated in tamoxifen (TAM)-resistant breast cancer cells, while the loss of TRIM4 is associated with an unfavorable prognosis. In vitro and in vivo experiments confirm that TRIM4 increased ER-α expression and the sensitivity of breast cancer cells to TAM.
View Article and Find Full Text PDFDisassociated and concurrent structural and functional abnormalities in the drug-naïve first-episode early onset schizophrenia.
Brain Imaging Behav
August 2022
Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder/Department of Psychiatry, First Hospital of Shanxi Medical University, No. 85 Jiefang Nan Road, Taiyuan, China.
Schizophrenia which is an abnormally developmental disease has been widely reported to show abnormal brain structure and function. Enhanced functional integration is a predominant neural marker for brain mature. Abnormal development of structure and functional integration may be a biomarker for early diagnosis of schizophrenia.
View Article and Find Full Text PDFNeural tracking of speech mental imagery during rhythmic inner counting.
Elife
October 2019
PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
The subjective inner experience of mental imagery is among the most ubiquitous human experiences in daily life. Elucidating the neural implementation underpinning the dynamic construction of mental imagery is critical to understanding high-order cognitive function in the human brain. Here, we applied a frequency-tagging method to isolate the top-down process of speech mental imagery from bottom-up sensory-driven activities and concurrently tracked the neural processing time scales corresponding to the two processes in human subjects.
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