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50 Years of Antibody Numbering Schemes: A Statistical and Structural Evaluation Reveals Key Differences and Limitations.
Antibodies (Basel)
December 2024
Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Background: The complementarity-determining region (CDR) of antibodies represents the most diverse region both in terms of sequence and structural characteristics, playing the most critical role in antibody recognition and binding for immune responses. Over the past decades, several numbering schemes have been introduced to define CDRs based on sequence. However, the existence of diverse numbering schemes has led to potential confusion, and a comprehensive evaluation of these schemes is lacking.
View Article and Find Full Text PDFThe HIV-1 Rev protein expressed in the early stage of virus replication is involved in the nuclear export of some forms of virus RNA. Naturally occurring polymorphisms in the Rev protein could influence its activity. The association between the genetic features of different virus variants and HIV infection pathogenesis has been discussed for many years.
View Article and Find Full Text PDFEffect of proprioceptive neuromuscular facilitation in the treatment of dysfunctions in facial paralysis: a systematic literature review.
Braz J Phys Ther
December 2022
Physiology Science Graduate Program, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brazil; Health Science Graduate Program, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brazil; Department of Physical Therapy, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brazil. Electronic address:
Background: Facial palsy (FP) is defined as an injury of the seventh cranial nerve pair, partial or total, which can be classified as central or peripheral. Proprioceptive neuromuscular facilitation (PNF) is primarily used in the functional recovery of upper and lower limb conditions, however the technique has also been used for FP.
Objective: To analyze the effect of PNF in the treatment of dysfunctions in FP.
Cross-population genetic analysis revealed genetic variation and selection in the gene of Indian sheep breeds.
Anim Biotechnol
December 2023
Veterinary College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University, Theni, India.
In sheep, MHC variability is studied widely to explore disease association. The aim of the current study was to explore the genetic diversity of -DRB diversity across sheep breeds of India. Here, DRB1 locus was studied across 20 sheep breeds.
View Article and Find Full Text PDFGenetic Diversity and Low Therapeutic Impact of Variant-Specific Markers in HIV-1 Pol Proteins.
Front Microbiol
July 2022
HIV-1 Molecular Epidemiology Laboratory, Department of Microbiology, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Hospital Universitario Ramón y Cajal, CIBER en Epidemiología y Salud Pública (CIBERESP), Red en Investigación Translacional en Infecciones Pediátricas (RITIP), Madrid, Spain.
The emergence and spread of new HIV-1 variants pose a challenge for the effectiveness of antiretrovirals (ARV) targeting Pol proteins. During viral evolution, non-synonymous mutations have fixed along the viral genome, leading to amino acid (aa) changes that can be variant-specific (V-markers). Those V-markers fixed in positions associated with drug resistance mutations (DRM), or R-markers, can impact drug susceptibility and resistance pathways.
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