Objective: To compare the risk factors such as age, menopause, menarche, age at the first pregnancy, number of pregnancies and breast feeding period between the familial and non-familial breast cancer females in Jordan.
Methods: This study was carried out in Al-Basheer Hospital, Amman, Jordan during the period 2000 and 2002. A questionnaire was used to collect information from 99 females who were histologically and pathologically diagnosed with breast cancer. Data of the questionnaire were entered and analyzed using statistical package for social sciences.
Results: The highest percentage of non-familial and familial breast cancer occurrence was among age group 51-60 years. The age of the first pregnancy is another risk factor of which the highest percentage of breast cancer was reported for both familial (57.1%) and non-familial (65.4) breast cancer females who have their first pregnancy while they were 20-years-old and above. More than 4 pregnancies also represents a risk factor for both non-familial (67.9%) and familial (68.6%) breast cancer patients. In this study, there are no statistical differences between menopause and menarche age among the breast cancer females. Finally, an inverse relationship was shown between breast feeding period (equal or more than 24 months) and the occurrence of breast cancer in both non-familial (2%) and familial (0%) breast cancer.
Conclusion: This study found that age 51-60 years and the increase number of pregnancies (more than 4) in the age of 20 years or more are risk factors for both types of breast cancer. On the other hand, longer period of breast feeding (more than 24 months) decreases the risk of breast cancer in both types.
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Biomol Biomed
January 2025
Necmettin Erbakan University, Meram Faculty of Medicine, Department of Medical Oncology, Konya, Turkey.
The cysteine-rich epidermal growth factor ligand domain 2 protein (CRELD2) is associated with pathways that regulate epithelial-to-mesenchymal transition, a critical process driving cancer metastasis. This study aimed to determine the prognostic value of CRELD2 status on survival outcomes in triple-negative breast cancer (TNBC). Seventy patients were included in the study.
View Article and Find Full Text PDFClin Cancer Res
January 2025
Mater Research Institute - University of Queensland, Woolloongabba, Qld, Australia.
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Clin Cancer Res
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Massachusetts General Hospital Cancer Center, Boston, MA, United States.
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Endocrine
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Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
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View Article and Find Full Text PDFBreast Cancer Res Treat
January 2025
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.
Purpose: Individuals with metastatic breast cancer (MBC) may live with their disease for many years. We initiated the Johns Hopkins Hope at Hopkins Clinic to assess the needs and optimize the care of these patients.
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