Our findings indicate that expression of matrix metalloproteinase-2 is an important prognostic marker of invasive potential of pancreatic tumors. Expression of this marker in neuroendocrine tumors (particularly in gastrinomas) can be used as a differential diagnostic criterion characterizing more malignant phenotype of tumors with the presence of ductal component. On the contrary, weak expression matrix metalloproteinase-9 is characteristic of less invasive phenotype of tumor cells (neuroendocrine and solid pseudopapillary tumors, mucinous cystadenomas). Co-expression of matrix metalloproteinases 2 and 9 is an unfavorable prognostic sign.
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