Histological examination of kidneys from mice experimentally infected with Toxocara canis embryonated eggs demonstrated the presence of a segmental or diffuse mesangioproliferative glomerulonephritis. Immunohistochemical studies established that renal alterations were associated with glomerular deposits of IgG, IgM and third component of complement (C3). These findings suggest that an immunomediated mechanism might possibly be involved in the genesis of kidney damage observed in mice infected with T. canis embryonated eggs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0304-4017(92)90068-k | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Analysis of Seroreactivity and Seropositivity in Balb/c Mice Experimentally Infected with Toxocara canis Using Two Recombinant (rTc-CTL-1 and rTES-120) Antigens.
Acta Parasitol
January 2025
Centralized Instrumentation Laboratory, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai, 600 007, India.
Introduction: Toxocarosis in human beings is currently diagnosed by serological assay based on the detection of antibodies against Toxocara antigens. Toxocara canis larvae do not reach the adult stage in paratenic hosts like humans and mice. Therefore experimental infection in mice, which mimics the biology of human infection, might be relevant to get a better understanding of human toxocarosis.
View Article and Find Full Text PDFThe Nematocidal Effect of Leiurus quinquestratus Scorpion Venom on Toxocara canis in Mice Model.
J Exp Zool A Ecol Integr Physiol
December 2024
Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt.
One neglected zoonotic illness is toxocariasis. There are not enough anthelmintic drugs in the market to treat low-effectiveness toxocariasis against migrating larvae. Therefore, it is critical to find new, safe alternatives to toxocariasis treatment today.
View Article and Find Full Text PDFComparison of different diagnostic protocols for the detection of Toxocara spp. in faecal samples of cats and dogs.
Parasit Vectors
October 2024
Institute of Epidemiology, Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.
Article Synopsis
- Toxocara canis and Toxocara cati are parasitic worms found globally, particularly posing risks to children through their eggs in the environment, highlighting the need for effective diagnostic methods for detection.
- This study compared different detection techniques including a new sequential sieving protocol and a high-throughput qPCR method, evaluating their efficiency on cat and dog faecal samples.
- Results indicated that the new sieving method was superior in sensitivity for egg detection, while mechanical lysis of DNA samples outperformed enzymatic lysis, and both DNA detection and microscopy methods showed comparable results with newer techniques being cost-effective.
Synergistic effects of using sodium hypochlorite (bleach) and desiccation in surface inactivation for Toxocara spp.
Exp Parasitol
June 2024
Cornell University College of Veterinary Medicine, Center for Animal Resources and Education (CARE), 930 Campus Road, Ithaca, NY, 14853, United States.
Toxocara cati and T. canis are parasitic nematodes found in the intestines of cats and dogs respectively, with a cosmopolitan distribution, and the potential for anthropozoonotic transmission, resulting in human toxocariasis. Spread of Toxocara spp.
View Article and Find Full Text PDFInfection in Cats (): A Systematic Review and Meta-Analysis.
Animals (Basel)
March 2024
Masters of Climate Change and Clinical Epidemiology and Biostatistics Program, Universidad Cientifica del Sur, Lima 15307, Peru.
Toxocariasis is an infection caused in canines, felines, humans, and other vertebrates by species of the genus , such as and . The embryonated eggs of these parasites are the primary means of acquiring the infection for both definitive hosts, dogs and cats, respectively, and for intermediates, such as humans and other vertebrates. When deposited on park soils, environmental contamination becomes a risk to environmental, human, and animal health.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!