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Endothelium Modulates the Prothrombotic Phenotype of Factor V Leiden: Evidence From an Ex Vivo Model.
Arterioscler Thromb Vasc Biol
January 2025
Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Germany.
Background: Clinical expressivity of the thrombophilic factor V Leiden (FVL) mutation is highly variable. Recently, we demonstrated an increased APC (activated protein C) response in asymptomatic FVL carriers compared with FVL carriers with a history of venous thromboembolism (VTE) after in vivo coagulation activation. Here, we further explored this association using a recently developed ex vivo model based on patient-specific endothelial colony-forming cells (ECFCs).
View Article and Find Full Text PDFEpigenetic Biomarkers in Thrombophilia-Related Pregnancy Complications: Mechanisms, Diagnostic Potential, and Therapeutic Implications: A Narrative Review.
Int J Mol Sci
December 2024
Department of Obstetrics and Gynecology, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Pregnancy complications associated with thrombophilia represent significant risks for maternal and fetal health, leading to adverse outcomes such as pre-eclampsia, recurrent pregnancy loss, and intra-uterine growth restriction (IUGR). They are caused by disruptions in key physiological processes, including the coagulation cascade, trophoblast invasion, angiogenesis, and immune control. Recent advancements in epigenetics have revealed that non-coding RNAs, especially microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and extracellular vesicles (EVs) carrying these RNAs, play crucial roles in the regulation of these biological processes.
View Article and Find Full Text PDFThe Microsurgical Resection of an Arteriovenous Malformation in a Patient with Thrombophilia: A Case Report and Literature Review.
Diagnostics (Basel)
November 2024
"Nicolae Oblu" Clinical Hospital, 700309 Iasi, Romania.
Arteriovenous malformations (AVMs) are complex vascular anomalies that can present with significant complications, including intracranial hemorrhage. This report presents the case of a 36-year-old female with Prothrombin G20210A mutation-associated thrombophilia, highlighting its potential impact on AVM pathophysiology and management. The patient presented with a right paramedian intraparenchymal frontal hematoma, left hemiparesis, and seizures.
View Article and Find Full Text PDFUnveiling the Unexpected: Lung Adenocarcinoma Presenting With Penile Mondor's Disease and Multiple Thrombotic Complications.
Cureus
October 2024
Respiratory Medicine, Iizuka Hospital, Iizuka, JPN.
Article Synopsis
- Penile Mondor's disease (PMD) is a rare and usually benign condition caused by thrombophlebitis of the superficial dorsal vein of the penis, but in this case, it was a sign of lung adenocarcinoma.
- A 46-year-old Japanese man initially presented with PMD, which led to the diagnosis of advanced stage IVA lung cancer, complicated by deep vein thrombosis and nonbacterial thrombotic endocarditis.
- This case emphasizes the need for doctors to consider potential underlying cancers in patients with unusual clotting issues, as well as the varied ways cancer can present itself.
Venous thromboembolism in patients with hairy cell leukemia.
Hematology
December 2024
Guthrie Robert Packer Hospital, Sayre, PA, USA.
Background: Hairy cell leukemia (HCL) is rare leukemia of mature B cells, accounting for 2% of all lymphoid neoplasms. Although the association of venous thromboembolism (VTE) with cancer is well established, there is no systematic study describing VTE in HCL.
Aim: To analyze prevalence and risk factors associated with VTE in HCL patients.
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