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Tyrosine-derived quinone cofactors. | LitMetric

Tyrosine-derived quinone cofactors.

Acc Chem Res

Department of Chemistry, University of California, Berkeley, California 94720, USA.

Published: February 2004

Copper amine oxidases (CAOs) and lysyl oxidase (LOX) both contain Cu(2+) and quinone cofactors that are derived from a tyrosine residue in the active site. In CAOs, the cofactor is 2,4,5-trihydroxyphenylalanine quinone (TPQ), and in LOX it is lysine tyrosyl quinone (LTQ). The mechanism of oxidative deamination by CAOs is well understood, but there is a controversy surrounding the role of Cu(2+) in cofactor reoxidation. The chemistry of LTQ in LOX, by contrast, has not been as extensively studied. This Account discusses the strategies that CAOs have evolved to control the mobility of TPQ to optimize activity. In addition, some recent studies on CAOs whose active-site Cu(2+) has been replaced with Co(2+) or Ni(2+) are summarized. Finally, there is a discussion on the properties of a model compound of LTQ and their relevance to the chemistry of LOX.

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Source
http://dx.doi.org/10.1021/ar9703342DOI Listing

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