[The observation of the effect of metronidazole-chlorhexidine solution on treatment of periapical periodontitis].

Objective: To observe the effect of metronidazole-chlorhexidine solution on treatment of periapical periodontitis.

Methods: 202 teeth suffering from chronic periapical periodontitis were selected and divided into two groups. One group including 102 teeth were treated with metronidazole-chlorhexidine solution. Another group including 100 teeth were treated with formocresol. The acute symptoms during root canal therapy were observed. 164 teeth suffering from acute periapical periodontitis were also selected and divided into two groups. One group including 80 teeth were treated with metronidazole-chlorhexidine solution. Another group including 84 teeth were treated as the above except the pulp chamber keeping open. The other 44 teeth, in which purulence also presented in the root canal after treated with formocresol and iodoform for three times or more, were treated with metronidazole-chlorhexidine solution. The presence of purulence was evaluated.

Results: There are significant differences between the two groups of chronic and acute periapical periodontitis(P<0.05). The effective rate was 97.6% after changed to metronidazole-chlorhexidine solution treatment.

Conclusion: Good treatment effect could be achieved by using metronidazole-chlorhexidine solution as the root canal cleaning and disinfection agent.