AI Article Synopsis
- The study aimed to explore the early stages of multiple organ injuries in rats caused by ischemia and reperfusion of the intestines and liver.
- Researchers used 75 male Wistar rats, dividing them into groups for hepatic ischemia, intestinal ischemia, and combined ischemia, measuring various biochemical markers at specific time points.
- Results indicated a significant decrease in superoxide dismutase (SOD) activity and an increase in markers for organ damage and stress, suggesting that intestinal ischemia may cause more severe early-stage injuries compared to hepatic ischemia.
Article Abstract
Objective: To investigate the early-stage multiple organ injuries in rats subjected to intestinal and hepatic ischemia-reperfusion.
Methods: Seventy-five normal male Wistar rats were randomized equally into hepatic ischemia, intestinal ischemia and intestinal-hepatic ischemia groups. Before and at the end of occlusion (45 min), as well as at the time points of 0.5, 2.0 and 6.0 h during the reperfusion, respectively, 5 rats from each group were killed to obtain samples for determination of the contents of malondialdehyde (MDA), superoxide dismutase (SOD) in the blood, lung, kidney, pancreas and heart tissues, along with blood urea nitrogen (BUN), amylase (AMY), and creatine kinase MB (CK-MB).
Results: The activity of SOD was decreased (P<0.05) and MDA, BUN, AMY and CK-MB levels increased significantly (P<0.05) after ischemia-reperfusion as compared with those before ischemia.
Conclusions: Intestinal and hepatic ischemia-reperfusion can induce injury of multiple organs at early stage. With the same duration of ischemia-reperfusion, intestinal ischemia may induce severer injury than hepatic ischemia.
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