The autoclaved cercarial vaccine (ACV) which is a special type of killed vaccine has been reported to induce experimental high level of homologous protective immunity. This study was to adjust the dose and to assess vaccine safety, longevity and stability as well as the possibility of transplacental transmission of immune response from pregnant mice to their offspring. The results showed that two doses of the lowest most effective concentration of ACV that achieved the high percentage reduction of worm burden is safe as demonstrated by absence of any local or systemic side effects, normal blood picture and normal liver and kidney function tests. ACV is stable when kept either at 4 degrees C for six months or at -35 degrees C for up to 12 months and it offered considerable duration of longevity. Offspring of vaccinated mothers didn't show any signs of protection against challenge infection.
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An experimental study for evaluating the efficacy of cercarial vaccine against Schistosoma mansoni.
J Egypt Soc Parasitol
December 2009
Department of Parasitology, Faculty of Medicine, Tanta University, Egypt.
Article Synopsis
- The study evaluated the effectiveness of an autoclaved cercarial vaccine (ACV) in protecting Swiss albino mice from Schistosoma mansoni infection by dividing them into a control group and several vaccinated groups.
- The vaccinated groups received different doses of the ACV, with the single 0.1 ml dose showing the best results in reducing infection levels.
- The findings indicated a significant decrease in adult worm numbers, liver and intestinal ova, and granuloma size, along with increased IL-10 mRNA expression in vaccinated mice compared to the control group.
Further studies on autoclaved cercarial vaccine against schistosomiasis: safety, longevity and stability.
J Egypt Soc Parasitol
August 2003
Department of Parasitology, Faculty of Medicine, Alexandria University, Egypt.
The autoclaved cercarial vaccine (ACV) which is a special type of killed vaccine has been reported to induce experimental high level of homologous protective immunity. This study was to adjust the dose and to assess vaccine safety, longevity and stability as well as the possibility of transplacental transmission of immune response from pregnant mice to their offspring. The results showed that two doses of the lowest most effective concentration of ACV that achieved the high percentage reduction of worm burden is safe as demonstrated by absence of any local or systemic side effects, normal blood picture and normal liver and kidney function tests.
View Article and Find Full Text PDFAutoclaved cercarial vaccine against schistosomiasis: ultrastructural and biochemical studies.
Southeast Asian J Trop Med Public Health
October 2001
Department of Parasitology, Faculty of Medicine, Alexandria University, Egypt.
Autoclaved cercarial vaccine (ACV) was found to be highly effective in eliciting protective immunity against experimental Schistosomal mansoni. So, the aim of this study was to analyse ACV biochemically and to study ultrastructural changes inflicted on the cercariae as a result of autoclaving, thus rendering it highly protective. Results of this study showed that approximately 100 microg protein and 44 microg carbohydrate were obtained from 10(3) cercariae.
View Article and Find Full Text PDFAutoclaved cercarial vaccine: a new hope against schistosomiasis parasitologic, histopathologic and immunologic studies.
J Egypt Soc Parasitol
August 1998
Department of Parasitology, Faculty of Medicine, Alexandria University, Egypt.
The efficacy of autoclaved cercarial vaccine (ACV) in eliciting protective immunity against Schistosoma mansoni infection was investigated in Swiss strain Albino mice. Two main groups of animals were used. One served as control group and the second was vaccinated with ACV mixed with Bacille Clamette-Guerin (BCG) as an adjuvant, in a single, double and triple doses 2 weeks apart.
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