AI Article Synopsis
- The study investigated the effects of colchicine and hydroxychloroquine on cyclo-oxygenases (COX) activity.
- Measurements were taken using whole blood assays and immunoassays for thromboxane (TXA) and prostaglandin 2 (PGE2).
- Results showed colchicine had no inhibitory effect on COX, while hydroxychloroquine showed mild inhibition at high concentrations, whereas standard COX inhibitors (like celecoxib) were effective.
Article Abstract
Objective: The aim of this study was to test whether colchicine and hydroxychloroquine have an inhibitory effect on cyclo-oxygenases (COX).
Methods: Measurement of COX-1 and COX-2 activity was performed by using whole blood assay. Serum thromboxane (TXA) and plasma prostaglandin 2 (PGE2) levels were determined using a commercially available enzyme immunoassay kit. Celecoxib, etodolac, and nimesulide were also tested as controls. Since the study was intended to find a qualitative effect rather than a quantitative relationship between the drugs and the enzymes, we used higher concentrations than the therapeutic range.
Results: Colchicine did not have an inhibitory effect on cyclo-oxygenases. Hydroxychloroquine had a mild inhibitory effect in a relatively high concentration. As expected, celecoxib, etodolac, and nimesulide did have an inhibitory effect on the cyclo-oxygenases.
Conclusions: Neither colchicine nor hydroxychloroquine exert their anti-inhibitory effect through inhibition of cyclo-oxygenases.
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| http://dx.doi.org/10.1007/s00296-004-0442-4 | DOI Listing |
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