Background: Propofol is frequently used for the induction and maintenance of anaesthesia in children aged 3 years and older. The present study compared the clinical and chemical effects of propofol containing disodium edetate (Diprivan) with that of sevoflurane in children younger than 3 years of age.

Methods: This was an open-label, comparative, parallel-group study. Fifty-six healthy children were randomly assigned to receive either propofol (n=28; mean age 14.7 months) or sevoflurane (n=28; mean age 13.2 months) for ambulatory surgical procedures. Anaesthesia was induced with nitrous oxide (60%), oxygen and sevoflurane (8%). In the propofol group, it was followed by an intravenous infusion of propofol at a rate of 200 microg.kg(-1).min(-1). For the sevoflurane group, anaesthesia was maintained with sevoflurane (1.5-2.5%). Haemodynamic measurements, recovery time and side-effects were recorded. Ionized calcium and magnesium concentrations in blood were measured. Statistical analysis was performed using ancova and the Fisher's exact test.

Results: The effects of propofol were similar to those of sevoflurane with respect to haemodynamic profile, recovery times (20 min vs 19.4 min) and side-effects (i.e. vomiting 10.7% vs 7.1%). Throughout the study, there were no significant differences between the mean ionized calcium and ionized magnesium concentrations in the two groups.

Conclusions: In children younger than 3 years of age, propofol containing ethylenediaminetetraacetic acid has a similar profile to sevoflurane with respect to haemodynamic effects, recovery times, side-effects, ionized calcium and ionized magnesium levels.

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http://dx.doi.org/10.1111/j.1460-9592.2004.01160.xDOI Listing

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