AI Article Synopsis
- A study examined patients with long-term effects from acute radiation sickness (ARS) and liquidators 5 years after the Chernobyl disaster, focusing on immune response indicators.
- Both groups exhibited high levels of autoantibodies targeting thymus epithelial cells, showing no significant differences in these antibody levels between the two groups.
- The antibodies identified were of the IgM class, and a correlation was found between serum IgM levels and the activity of these autoantibodies, using both human and mouse thymus tissue for analysis.
Article Abstract
A group of patients, suffering from sequelae of acute radiation sickness (ARS), and liquidators was studied 5 years after exposure to a complex of factors resulting from the Chernobyl A.P.S. disaster. Studied were: the antibody titres to antigens of the cytoplasm of thymus epithelial reticulum cells and to Hassall's corpuscles the levels of serum immunoglobulins M, G, A; and the content of serum alpha 1-thymosin. Patients with ARS sequelae and liquidators showed a high level and incidence of autoantibodies to antigens of cytoplasm of thymus epithelial reticulum cells and to Hassall's corpuscles. There were no significant differences between the antibody levels in the blood of patients with ARS sequelae and liquidators. The antibodies were found to belong to IgM class; there was a correlation between the serum IgM titres and the rate of the indirect immunofluorescence reaction with autoantibodies to antigens of the cytoplasm of the thymus epithelial reticulum cells. To identify autoantibodies cryostat sections of human and mouse, (CBA x C57BL/6) F1, thymus as well as the epithelial and stromal cell culture of mouse thymus can equally be used.
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