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miR-468-3p suppresses osteogenic differentiation of BMSCs by targeting Runx2 and inhibits bone formation.
J Orthop Surg Res
December 2024
Department of Cardiology, Qingdao Municipal Hospital, 1 Jiaozhou Road, Qingdao, Shandong, 266000, China.
An improved understanding of the molecular actions underpinning bone marrow mesenchymal stem cell (BMSC) differentiation could highlight new therapeutics for osteoporosis (OP). Current evidence indicates that microRNAs (miRNAs) exert critical roles in many biological systems, including osteoblast differentiation. In this study, we examined miR-468-3p effects on osteogenic differentiation (OD).
View Article and Find Full Text PDFCBFβ Regulates RUNX3 ADP-Ribosylation to Mediate Homologous Recombination Repair.
J Cell Physiol
January 2025
Department of Cancer Biology, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA.
RUNX3 is a master developmental transcriptional factor that has been implicated as a tumor suppressor in many cancers. However, the exact role of RUNX3 in cancer pathogenesis remains to be completely elucidated. Recently, it has emerged that RUNX3 is involved in the DNA damage response.
View Article and Find Full Text PDFTensile stress induced osteogenesis of periodontal ligament cells via Piezo1 mediated TAZ-Cbfα1 signaling.
Arch Oral Biol
November 2024
Department of Orthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:
Objective: Cyclic tensile stress (CTS) is known to induce osteogenesis of periodontal ligament cells (PDLCs), in which the molecular mechanism remains to be elucidated. This study aimed to investigate the role of the mechanosensitive calcium channel Piezo1 in the osteogenesis of PDLCs under tensile strain, as well as the signal regulation of the TAZ-Cbfα1 pathway in this process.
Design: PDLCs were isolated from periodontal ligament tissues and subjected to CTS.
"A Friend Among Strangers" or the Ambiguous Roles of Runx2.
Biomolecules
October 2024
Laboratory of Regenerative Biomedicine, Institute of Cytology, Russian Academy of Sciences, 194064 Saint-Petersburg, Russia.
The transcription factor Runx2 plays a crucial role in regulating osteogenic differentiation and skeletal development. This factor not only controls the expression of genes involved in bone formation, but also interacts with signaling pathways such as the Notch pathway, which are essential for body development. However, studies have produced conflicting results regarding the relationship between Runx2 and the Notch pathway.
View Article and Find Full Text PDFRedistribution of PU.1 partner transcription factor RUNX1 binding secures cell survival during leukemogenesis.
EMBO J
December 2024
Institute of Molecular Tumor Biology, University of Münster, Münster, Germany.
Transcription factors (TFs) orchestrating lineage-development often control genes required for cellular survival. However, it is not well understood how cells survive when such TFs are lost, for example in cancer. PU.
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