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Relationship Between Radiation Therapy and Fecal Incontinence in Patients Treated for Localized Prostate Cancer: Results of the French ICONES Study.
Prostate
January 2025
AP-HP. Department of Urology, Henri Mondor University Hospital, Creteil, France.
Background: Radiation-induced late fecal incontinence (LFI) is one of the most quality-of-life impairing symptoms in prostate cancer. We aimed to assess the impact of radiotherapy (RT) technique and dose-volume effects on LFI using a robust score.
Methods: We identified 409 patients who underwent curative intent using standard fractionated radiation therapy, 190 of them were finally included and analyzed.
Study of the cortico-anorectal neurophysiology in women with fecal incontinence.
Am J Gastroenterol
January 2025
Gastrointestinal Physiology Laboratory, Department of Surgery, Hospital de Mataró (Universitat Autònoma de Barcelona), Carretera de Cirera s/n 08304, Mataró, Spain.
Background: Fecal incontinence (FI) is a prevalent condition that disproportionately impacts women. Although sphincter biomechanics are well studied, the integrity of the cortico-anal motor pathway remains elusive. We evaluated the cortico-spino-anorectal pathway in women with FI against age-matched (AM-HV) and young healthy (Y-HV) volunteers.
View Article and Find Full Text PDFThe Effect of Biofeedback on Constipation, Sleep, Depression, Anxiety and Quality of Life in Patients with Dyssynergic Defecation: a QUASI Experimental Study (Before and After Study).
Appl Psychophysiol Biofeedback
January 2025
Physical Medicine and Rehabilitation Department, Arash Women General Hospital, Tehran University Of Medical Sciences, Tehran, Iran.
Dyssynergic defecation(DD) is the inability to coordinate abdominal and anorectal muscle contraction during defecation. Patients with constipation often report poor quality of life, sleep issues, and increased risk of mood disorders. Biofeedback is a recommended treatment for DD.
View Article and Find Full Text PDFEnhancing Post-Surgical Wound Care in Anorectal Diseases: A Comparative Study of Advanced Convolutional Neural Network (CNN) Architectures for Image Classification and Analysis.
Ann Ital Chir
December 2024
Department of Colorectal Surgery, Hubei Provincial Hospital of Traditional Chinese Medicine Affiliated to Hubei University of Chinese Medicine, 430071 Wuhan, Hubei, China.
Aim: Anorectal diseases, often requiring surgical intervention and careful post-operative wound management, pose substantial challenges in healthcare. This study presents a novel application of artificial intelligence, specifically machine learning, aimed at improving the classification and analysis of post-surgical wound images. By doing so, it seeks to enhance patient outcomes through personalized and optimized wound care strategies.
View Article and Find Full Text PDFThe METTL3/m6A Reader Protein YTHDF1 Regulates Endothelial Cell Pyroptosis by Enhancing NLRP3 Expression to Affect Soft Tissue Injury.
J Inflamm Res
December 2024
Department of Anorectal, Xiangtan Central Hospital, Xiangtan, 411100, People's Republic of China.
Background: Pyroptosis is inflammation-associated programmed cell death triggered by activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, which plays a crucial role in acute soft tissue injury (ASTI). This study aimed to explore whether methyltransferase-like 3 (METTL3) can regulate NLRP3 expression through N6-methyladenosine (m6A) modification to mediate endothelial cell pyroptosis and thus affect soft tissue injury.
Methods: An experimental ASTI rat model was created by inducing muscle injury through striking the rat muscle.
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