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What is new in the pathogenesis and treatment of IgA glomerulonephritis.
World J Nephrol
December 2024
Division of Nephrology, San Giovanni di Dio Hospital, Florence 50143, Toscana, Italy.
Recently, new findings have been clarified concerning both pathogenesis and treatment of IgA nephritis. The four hits theory has been confirmed but several genetic wide association studies have allowed finding several genes connected with the pathogenesis of the disease. All these new genes apply to each of the four hits.
View Article and Find Full Text PDFCoexistence of Fabry Disease and Membranous Nephropathy: A Case Report.
Iran J Kidney Dis
August 2024
Department of Nephrology, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.
Article Synopsis
- * A renal biopsy revealed abnormal deposits in the glomeruli and features indicating FD, supported by a specific genetic mutation and low enzyme activity confirming the diagnosis.
- * After treatment with ramipril initially reduced protein levels in urine, the proteinuria returned, leading to ongoing treatment with allisartan isoproxil, which has not yet been effective in resolving the issue.
Supportive Treatment of a Dog with Leishmaniosis and Severe Glomerulopathy with Immunoadsorption.
Pathogens
February 2024
LMU Small Animal Clinic, Centre for Clinical Veterinary Medicine, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München, 80539 Munich, Germany.
A three-year-old, intact female mix-breed dog, weighing 30 kg, was presented due to vomitus and diarrhea. At presentation, the patient had a slightly reduced general condition and moderately enlarged mandibular and popliteal lymph nodes. The initial blood work showed severe azotemia and hypoalbuminemia.
View Article and Find Full Text PDFLupus-like membranous nephropathy during the postpartum period expressing glomerular antigens exostosin 1/exostosin 2 and phospholipase A2 receptor: a case report.
CEN Case Rep
October 2024
Department of Nephrology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Recently, several target antigens of membranous nephropathy (MN), such as phospholipase A2 receptor (PLA2R) and exostosin 1/exostosin 2 (EXT1/2), have been discovered. A 30-year-old woman was referred to our hospital with nephrotic range proteinuria and microscopic hematuria. She was first noted to have proteinuria before pregnancy, and her proteinuria worsened in the postpartum period.
View Article and Find Full Text PDFCyclophosphamide Toxicity in Pediatric Nephrotic Syndrome Patient: A Case Report and Literature Review.
Curr Drug Saf
August 2024
Department of Pharmacy Practice, KLE College of Pharmacy, A Constituent Unit of KLE Academy of Higher Education and Research (KAHER), Belgaum-590010, Karnataka, India.
Background: Primary membranous nephropathy is a rare presentation in children. Patients unresponsive to steroids and experiencing frequent relapse are considered steroid-resistant. They often require complex treatment regimens consisting of immunosuppressants like cyclophosphamide, tacrolimus, and cyclosporin A.
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