In unrestrained cats parachlorophenylalanine, an inhibitor of serotonin synthesis, increased the thresholds of the contraversive reaction and arrest reaction accompanied by spindle-waves in the sensory-motor cortex in the stimulation of the rostro-ventral areas of the caudate nucleus. The reactions evoked from the dorso-medial areas of the head and the body of the nucleus changed differently. On the contrary, 5-hydroxytryptophane, serotonin precursor, increased most of the indices of the caudate activity independently of the site of stimulation. It is suggested that the serotoninergic mechanisms (antagonistic to the dophaminergic system) existing in the ventral part of the caudate nucleus may trigger some caudate functions.
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