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Background: Piriformis syndrome, which is seen as the cause of 0.3% to 6% of low back pain, is a painful condition that occurs as a result of compression of the piriformis muscle on the sciatic nerve. Although there are many studies in the literature about piriformis syndrome, no bibliometric analysis has been found.

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Usually, coccydynia cases are caused by herniated discs, with lower back pain and sciatica as initial symptoms. However, whether lumbar disc herniation causes coccydynia without back pain remains unclear. We report a case of lumbar disc herniation diagnosed as the underlying cause of coccydynia by discoblock.

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Causal relationship between hypothyroidism and peripheral neuropathy: a Mendelian randomization study of European ancestry.

Front Endocrinol (Lausanne)

December 2024

Acupuncture Anaesthesia Clinical Research Institute, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Background: Metabolic disorders are significant risk factors for peripheral neuropathy (PN) diseases. However, current clinical observational studies cannot fully determine the causal relationships between hypothyroidism (HT) and PN diseases.

Methods: We performed univariate Mendelian randomization (MR) analyses using single nucleotide polymorphisms (SNPs) associated with hypothyroidism and two diseases clinically presented as HT (autoimmune thyroid disease and benign neoplasm of the pituitary gland and craniopharyngeal duct) as instrumental variables.

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Effectiveness of ozone nucleolysis in alleviating pain and enhancing function in lumbar sciatica due to disc herniation: a minimally invasive approach.

Clin Rheumatol

January 2025

Cell Therapy and Experimental Surgery of Musculoskeletal System LR18SP11 Lab, Medicine Faculty of Sfax, University of Sfax, Majida Boulila Road, 3029, Sfax, Tunisia.

Article Synopsis
  • Ozone nucleolysis is a minimally invasive treatment that has shown promise for relieving pain from herniated discs, particularly in patients with lumbosciatica.
  • A study involving 34 patients demonstrated that 85% experienced pain relief after treatment, with better outcomes noted in younger patients and specific types of disc herniations.
  • Overall, ozone therapy is considered a safe, cost-effective option that could help patients avoid more invasive surgical procedures while improving their quality of life.
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Objective: The Qing'e Pill (QEP) is widely used to alleviate low back pain and sciatica caused by Intervertebral Disc Degeneration (IDD). However, its active components, key targets, and molecular mechanisms are not fully understood. The aim of this study is to elucidate the molecular mechanisms through which the QEP improves IDD using database mining techniques.

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