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Prevalence and level of stress among final-year students at a health science institute in Bangladesh.
Discov Ment Health
January 2025
Department of Rehabilitation Science, Bangladesh Health Professions Institute (BHPI), CRP, Savar, Dhaka-1343, Bangladesh.
Background: Final-year students studying in various health science institutes are usually very stressed about their studies so that they can complete their studies without any hurdles. This stress can lead to poor academic and professional results because psychological issues such as anxiety and depression are frequently overlooked and not treated. This study aimed to measure the prevalence of stress and also assess the level of stress symptoms among the final year students of health science institute in Bangladesh.
View Article and Find Full Text PDFCaution when using network partners for target identification in drug discovery.
HGG Adv
January 2025
Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada; Department of Human Genetics, McGill University, Montréal, Québec, Canada; 5 Prime Sciences Inc, Montréal, Quebec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, QC, Canada; Department of Medicine, McGill University, Montréal, Québec, Canada; Department of Twin Research, King's College London, London, UK. Electronic address:
Identifying novel, high-yield drug targets is challenging and often results in a high failure rate. However, recent data indicates that leveraging human genetic evidence to identify and validate these targets significantly increases the likelihood of success in drug development. Two recent papers from Open Targets claimed that around half of FDA-approved drugs had targets with direct human genetic evidence.
View Article and Find Full Text PDFBlood Biomarkers as a Non-Invasive Method for the Assessment of the State of the Fontan Circulation.
J Clin Med
January 2025
Department of Preventive Cardiology and Lipidology, Medical University of Lodz, 90-419 Lodz, Poland.
The Fontan operation has become the primary palliative treatment for patients with a functionally univentricular heart. The population of patients with Fontan circulation is constantly growing and aging. As the number of Fontan patients surviving into adulthood increases, there is a clear need for research on how best to follow these patients and manage their complications.
View Article and Find Full Text PDFNumerical Simulation of Compressive Testing of Sandwich Structures with Novel Triply Periodic Minimal Surface Cores.
Materials (Basel)
January 2025
Department of Strength of Materials, National University for Science and Technology POLITEHNICA Bucharest, Splaiul Independeţei 313, 060042 Bucharest, Romania.
Sandwich structures with triply periodic minimal surface (TPMS) cores have garnered research attention due to their potential to address challenges in lightweight solutions, high-strength designs, and energy absorption capabilities. This study focuses on performing finite element analyses (FEAs) on eight novel TPMS cores and one stochastic topology. It presents a method of analysis obtained through implicit modeling in simulations and examines whether the results obtained differ from a conventional method that uses a non-uniform rational B-spline (NURBS) approach.
View Article and Find Full Text PDFEfficacy and safety of mechanical thrombectomy in patients with acute ischemic stroke and left ventricular assist device: review of the literature and meta-analysis.
J Neurointerv Surg
January 2025
Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Background: Left ventricular assist devices (LVADs) are used as definitive therapy or as a bridge to heart transplant in patients with advanced heart failure. Thromboembolic complications such as acute ischemic stroke (AIS) are common among patients with LVAD support. This study aims to evaluate the current evidence on the efficacy and safety of mechanical thrombectomy (MT) in patients with AIS due to large vessel occlusions (LVO) and LVAD-support.
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