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Prenatal exposure to synthetic chemicals in relation to HPA axis activity: A systematic review of the epidemiological literature.
Sci Total Environ
December 2024
Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USA; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USA. Electronic address:
Background: Pregnant people are widely exposed to numerous synthetic chemicals with known endocrine-disrupting properties (e.g., phthalates, phenols, per- and poly-fluoroalkyl substances (PFAS)).
View Article and Find Full Text PDFProgressive 11β-Hydroxysteroid Dehydrogenase Type 2 Insufficiency as Kidney Function Declines.
J Clin Endocrinol Metab
September 2024
Center for Adrenal Disorders, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA.
Background: It has been postulated that chronic kidney disease (CKD) is a state of relative 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) insufficiency, resulting in increased cortisol-mediated mineralocorticoid receptor (MR) activation. We hypothesized that relative 11βHSD2 insufficiency manifests across a wide spectrum of progressively declining kidney function, including within the normal range.
Methods: Adult participants were recruited at two academic centers.
Impaired 11β-HSD1 Activity in a Male Patient With Cushing Disease Resulting in Lack of the Full Cushingoid Phenotype.
JCEM Case Rep
September 2024
Department of Medicine, Division of Endocrinology, University of California, San Francisco, CA 94143, USA.
Article Synopsis
- A case study discusses a patient with surgical confirmation of Cushing's disease (CD) who had significantly high cortisol levels but did not display typical symptoms associated with the condition.
- The investigation ruled out other causes of elevated ACTH and cortisol, and revealed reduced activity of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which plays a crucial role in regulating cortisol levels in cells.
- The findings suggest that impaired 11β-HSD1 may explain the absence of classic Cushing's features in patients with high cortisol, highlighting its importance in diagnosing such cases.
Corticosteroid rhythms in hypoparathyroid patients.
Eur J Endocrinol
August 2024
Department of Clinical Medicine and KG Jebsen-Center for Autoimmune Diseases, University of Bergen, 5020 Bergen, Norway.
Objective: Previous studies indicate a possible bidirectional stimulatory relationship between parathyroid hormone (PTH) and adrenocortical hormones, but the pattern of adrenocortical secretion in hypoparathyroidism is unknown. We aimed to characterize the adrenocortical secretion in patients with postsurgical hypoparathyroidism, and whether continuous subcutaneous PTH (1-34) infusion alters secretion patterns.
Design: Crossover interventional study.
Impact of systemic treatments for advanced thyroid cancer on the adrenal cortex.
Eur Thyroid J
June 2024
Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy.
Background: Fatigue is a frequent adverse event during systemic treatments for advanced thyroid cancer, often leading to reduction, interruption, or discontinuation. We were the first group to demonstrate a correlation between fatigue and primary adrenal insufficiency (PAI).
Aim: The objective was to assess the entire adrenal function in patients on systemic treatments.
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