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Background: Understanding the fundamental differences between the human and pre-human brain is a prerequisite for designing meaningful models and therapies for AD. Expressed CHRFAM7A, a human restricted gene with carrier frequency of 75% in the human population predicts profound translational significance.
Method: The physiological role of CHRFAM7A in human brain is explored using multiomics approach on 600 post mortem human brain tissue samples (ROSMAP).
[Expert consensus on ethical requirements for artificial intelligence (AI) processing medical data].
Sheng Li Xue Bao
December 2024
Virtual Simulation and Artificial Intelligence Committee, Chinese Association for Physiological Sciences.
As artificial intelligence technology rapidly advances, its deployment within the medical sector presents substantial ethical challenges. Consequently, it becomes crucial to create a standardized, transparent, and secure framework for processing medical data. This includes setting the ethical boundaries for medical artificial intelligence and safeguarding both patient rights and data integrity.
View Article and Find Full Text PDFSeeing in the Future - a Perspective on Combining Light with Chemical Biology Approaches to Treat Retinal Pathologies.
ChemMedChem
January 2025
Department of Physiological Chemistry, University Medical Center of Johannes Gutenberg University Mainz, 55128, Mainz, Germany.
New concepts to treat eye diseases have emerged that elegantly combine unnatural light exposure with chemical biology approaches to achieve superior cellular specificity and, as a result, improvement of visual function. Historically, light exposure without further molecular eye treatment has offered limited success including photocoagulation to halt pathological blood vessel growth or low light exposure to stimulate retinal cell viability. To add cellular specificity to such treatments, researchers have introduced various biological or chemical light-sensing molecules and combined those with light exposure.
View Article and Find Full Text PDFProgression of serum creatinine and glomerular filtration rate in neonatal critical care patients during the first seven days of life.
Pediatr Nephrol
January 2025
University of Castilla La Mancha, Albacete, Spain.
Background: Serum creatinine and estimated glomerular filtration rate (GFR) are key indicators of kidney function.
Methods: This descriptive, retrospective study included neonatal patients admitted to a tertiary hospital's neonatal intensive care unit from January 2013 to December 2016. Data on kidney function were collected from birth to 7 days of life.
Multivariate Modelling and Prediction of High-Frequency Sensor-Based Cerebral Physiologic Signals: Narrative Review of Machine Learning Methodologies.
Sensors (Basel)
December 2024
Department of Biomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB R3T 5V6, Canada.
Monitoring cerebral oxygenation and metabolism, using a combination of invasive and non-invasive sensors, is vital due to frequent disruptions in hemodynamic regulation across various diseases. These sensors generate continuous high-frequency data streams, including intracranial pressure (ICP) and cerebral perfusion pressure (CPP), providing real-time insights into cerebral function. Analyzing these signals is crucial for understanding complex brain processes, identifying subtle patterns, and detecting anomalies.
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