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Update on the evolving landscape of pneumococcal capsule types: new discoveries and way forward.
Clin Microbiol Rev
January 2025
Department of Medicine, Division of Pulmonary/Allergy/Critical Care, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
SUMMARY (the "pneumococcus") is a significant human pathogen. The key determinant of pneumococcal fitness and virulence is its ability to produce a protective polysaccharide (PS) capsule, and anti-capsule antibodies mediate serotype-specific opsonophagocytic killing of bacteria. Notably, immunization with pneumococcal conjugate vaccines (PCVs) has effectively reduced the burden of disease caused by serotypes included in vaccines but has also spurred a relative upsurge in the prevalence of non-vaccine serotypes.
View Article and Find Full Text PDFThe Important Round-Trip Energy Transfer for Excitation of the Red Emission in the Er/Yb System.
J Phys Chem Lett
January 2025
State Key Laboratory of Luminescence Science and Technology, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, 3888 Eastern South Lake Road, Changchun, 130033, China.
Round-trip energy transfer (RTET) in the popular Er/Yb upconversion (UC) system is a newly discovered mechanism for the red emission of Er through Yb as an intermediate ion. However, the importance of the RTET still remains a question. Here, we show in cubic YO that the new mechanism defeats conventional ones and dominates the red emission in both UC and down-shifting (DS) luminescence for a wide concentration range of Yb.
View Article and Find Full Text PDFSerinophospholipids: A Third Type of Natural Phospholipid Discovered in a Thermophilic Bacterium.
J Nat Prod
January 2025
The Ferrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand 6012.
Phospholipids are an essential constituent of cells with all life thought to produce these compounds with either a glycerol or sphingoid moiety at their core. For the first time, we demonstrate that a thermophilic bacterium, NGM72.4, produces a third type of phospholipid, serinophospholipids, which are distinct from glycero- and sphingophospholipids by featuring a serinol backbone instead.
View Article and Find Full Text PDFBiochemical characteristics, genetic variants and treatment outcomes of 55 Chinese cases with neonatal intrahepatic cholestasis caused by citrin deficiency.
Front Pediatr
January 2025
Department of Gastroenterology, Kunming Children's Hospital, Kunming, China.
Background: The diagnostic criteria of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) have not been established due to non-specific clinical manifestations, and our understanding on the treatment outcome is still limited. We aim to investigate the biochemical characteristics, genetic variants, and treatment outcome of NICCD patients.
Methods: We compared the nutritional status and biochemical characteristics of 55 NICCD infants and 27 idiopathic neonatal cholestasis (INC) infants.
Integrative analysis of cuproptosis-related lncRNAs: Unveiling prognostic significance, immune microenvironment, and copper-induced mechanisms in prostate cancer.
Cancer Pathog Ther
January 2025
Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China.
Background: Long non-coding ribonucleic acids (lncRNAs) regulate messenger RNA (mRNA) expression and influence cancer development and progression. Cuproptosis, a newly discovered form of cell death, plays an important role in cancer. Nonetheless, additional research investigating the association between cuproptosis-related lncRNAs and prostate cancer (PCa) prognosis is required.
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