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Laboratory tests in the diagnosis and follow-up of pediatric rheumatic diseases: an update.
Semin Arthritis Rheum
August 2010
Department of Pediatrics, Reumathology Unit, University of Chieti, Chieti, Italy.
Objectives: We reviewed the literature to evaluate the role of common laboratory tests and to examine the recent progress in the laboratory diagnosis of pediatric rheumatic diseases.
Methods: We used the PubMed database (1950-2008) to search for the keywords "laboratory," "erythrocyte sedimentation rate" (ESR), "C-reactive protein" (CRP), "blood cytology," "procalcitonin" (PCT), "complement system," "ferritin," "antistreptolysin O titer" (ASO), "autoantibodies," "genetic studies," in conjunction with "rheumatic disease in children" and "pediatric autoimmune diseases." All relevant original and review articles in English were reviewed as well as textbooks of pediatric rheumatology.
Evaluation of poststreptococcal illness.
Am Fam Physician
May 2005
Department of Family Medicine, University of Southern California, Los Angeles, California, USA.
Group A beta-hemolytic streptococcal pharyngitis, scarlet fever, and rarely asymptomatic carrier states are associated with a number of poststreptococcal suppurative and nonsuppurative complications. As in streptococcal pharyngitis, acute rheumatic fever, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection, and poststreptococcal glomerulonephritis most often occur in children. The hallmarks of rheumatic fever include arthritis, carditis, cutaneous disease, chorea, and subsequent acquired valvular disease.
View Article and Find Full Text PDFPolyarteritis nodosa (PAN) is a multisystem inflammatory disease associated with necrotizing vasculitis of small and medium arteries. Although predominantly an adult disease, PAN is well described in children. It can occur in a systemic form with manifestations in skin, joints, heart, nervous system, gastrointestinal tract, lungs and kidneys, and a limited form in which disease is confined to the skin, muscles, joints and peripheral nerves.
View Article and Find Full Text PDFThe sensitivity of enzyme immunoassay (EIA) of antistreptokinase, a new method for its measurements, is 10 times higher than the sensitivity of the prototype method. EIA is more sensitive than the prototype method, the incorrectness of the latter being ruled out; endogenous substrates, patients's blood fibrinogen and plasminogen, are used, whose concentrations vary in streptococcal diseases. Effects of nonspecific blood proteinase which, together with streptokinase, may cause a proteolytic effect, on the results of analysis are also ruled out.
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