The influence of co-trimoxazole on colonization resistance of the bowel was investigated in six healthy volunteers, by measuring the numbers of indigenous aerobic flora and of a co-trimoxazole resistant challenge strain of Klebsiella pneumoniae. Impairment of colonization resistance of the bowel was shown by a significant increase in the numbers of yeasts in the faeces of five of six volunteers, by a significant increase in the numbers of Gram-negative bacilli in the faeces of two of six volunteers, and by facilitation of colonization of the bowel by the challenge strain in all volunteers. Impairment of colonization resistance of the mouth was shown by the development of glossitis caused by Candida albicans in two volunteers, and by a significant increase in the numbers of yeasts in mouth washings from four volunteers. It is concluded that co-trimoxazole impairs colonization resistance of the gastro-intestinal tract.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/jac/30.5.685 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Targeted sequencing of bacteria using CRISPR-Cas9 enrichment and Oxford Nanopore Technologies.
mSystems
January 2025
Department of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Unlabelled: Sequencing DNA directly from patient samples enables faster pathogen characterization compared to traditional culture-based approaches, but often yields insufficient sequence data for effective downstream analysis. CRISPR-Cas9 enrichment is designed to improve the yield of low abundance sequences but has not been thoroughly explored with Oxford Nanopore Technologies (ONT) for use in clinical bacterial epidemiology. We designed CRISPR-Cas9 guide RNAs to enrich the human pathogen , by targeting multi-locus sequence type (MLST) and transfer RNA (tRNA) genes, as well as common antimicrobial resistance (AMR) genes and the resistance-associated integron gene .
View Article and Find Full Text PDFSmall RNA CjNC110 regulates the activated methyl cycle to enable optimal chicken colonization by .
mSphere
January 2025
Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.
Post-transcriptional gene regulation by non-coding small RNAs (sRNAs) is critical for colonization and survival of enteric pathogens, including the zoonotic pathogen . In this study, we utilized IA3902 (a representative isolate of the sheep abortion clone) and W7 (a highly motile variant of NCTC 11168, a human gastroenteritis strain) to further investigate regulation by sRNA CjNC110. Both motility and autoagglutination ability were confirmed to be phenotypes of conserved regulation by CjNC110.
View Article and Find Full Text PDF/ Infection: Is It Still a Concern?
Microorganisms
December 2024
Pediatric Infectious Disease Unit, Barilla Children's Hospital of Parma, 43126 Parma, Italy.
Campylobacteriosis is a leading cause of infectious diarrhea and foodborne illness worldwide. infection is primarily transmitted through the consumption of contaminated food, especially uncooked meat, or untreated water; contact with infected animals or contaminated environments; poultry is the primary reservoir and source of human transmission. The clinical spectrum of / infection can be classified into two distinct categories: gastrointestinal and extraintestinal manifestations.
View Article and Find Full Text PDFElimination of Methicillin-Resistant from Mammary Glands of Dairy Cows by an Additional Antibiotic Treatment Prior to Dry Cow Treatment.
Microorganisms
December 2024
Department Biological Safety, German Federal Institute for Risk Assessment, 10589 Berlin, Germany.
Methicillin-resistant (MRSA) have been isolated from quarter milk samples of dairy cows, raising concerns over transmission to consumers of raw milk. This study investigates whether pre-treatment before dry-off can increase the success rate of dry cow treatment against MRSA. MRSA positive cows were assigned to two treatment groups.
View Article and Find Full Text PDFGenetic Characterization, Transmission Pattern and Health Risk Analysis of Intestinal Colonization ESBL-Producing in Vegetable Farming Population.
Microorganisms
December 2024
Department of Environment and Health, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
The surging prevalence rates of ESBL-producing (ESBL-Ec) pose a serious threat to public health. To date, most research on drug-resistant bacteria and genes has focused on livestock and poultry breeding areas, hospital clinical areas, natural water environments, and wastewater treatment plants. However, few studies have been conducted on drug-resistant bacteria in vegetable cultivation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!