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A contemporary, multiinstitutional analysis of transcription factor lineage in pituitary adenomas: comparative study of neuroimaging, histopathology, and clinical outcomes.
J Neurosurg
March 2025
1Department of Neurological Surgery, University of Southern California, Keck School of Medicine, Los Angeles, California.
Objective: Pituitary adenomas (PAs) are common lesions that often present with endocrinopathy and/or visual symptoms. Classification of PAs has historically been based on functional status and histopathological staining of anterior pituitary hormones. In 2017, the WHO revised the classification of PAs, establishing cell lineages identified by the transcription factors (TFs) PIT1, TPIT, and SF1.
View Article and Find Full Text PDFEndocrine paraneoplastic syndromes in lung cancer: A call for clinical vigilance (Review).
Mol Clin Oncol
April 2025
Department of Pathophysiology, Laiko General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Endocrine paraneoplastic syndromes (PNS) are uncommon but clinically impactful manifestations associated with malignancies, particularly lung cancer, most notably small-cell lung cancer. These syndromes arise from ectopic hormone production by malignant cells, causing systemic effects that are independent of direct tumor invasion or metastasis. Their presentation often precedes or signals recurrence of the primary cancer, underscoring the importance of early recognition and targeted intervention.
View Article and Find Full Text PDFPsychiatric morbidity in acromegaly: a cohort study and meta-analysis of the literature.
Pituitary
March 2025
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.
Purpose: We aimed to evaluate the risk of psychiatric disorders through a retrospective cohort study comparing acromegaly and non-functioning pituitary adenomas (NFPAs) and a meta-analysis of existing literature.
Methods: The cohort study included data from patient records analyzed using Chi-, T-tests and binary regression. The meta-analysis included studies retrieved from PubMed, Embase and PsycINFO that reported risk of psychopathology in acromegaly compared to NFPA or healthy controls, using a random effects model.
Headache characteristics in acromegaly: Only a secondary disorder?
Headache
March 2025
Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy.
Objective: To investigate the characteristics and nature of headache in a population of patients with acromegaly.
Background: Headache is frequently described by patients with pituitary adenomas. Although it is mainly considered a secondary disorder, it can persist despite effective therapy for pituitary disease.
Musculoskeletal disease in acromegaly - a population-based registry study.
Eur J Endocrinol
March 2025
Unrestricted research grant from Pfizer and Ipsen; Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark and Steno Diabetes Center North Jutland, Aalborg, Denmark.
Objective: Acromegaly is associated with multiple musculoskeletal complications that affect quality of life and work ability. We aimed to examine the risk of osteoarthritis, musculoskeletal surgery (incl. joint replacement), osteoporosis, fractures and analgesic consumption in Danish acromegaly patients.
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