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Herpes Zoster and Post-Herpetic Neuralgia-Diagnosis, Treatment, and Vaccination Strategies.
Pathogens
July 2024
National Skin Centre, Singapore 308205, Singapore.
Article Synopsis
- Herpes zoster results from the reactivation of the varicella-zoster virus, leading to painful, unilateral skin eruptions, with potential complications like eye issues and long-term pain.
- Diagnosis is primarily clinical but can be supported by lab tests; early antiviral treatment can lessen symptoms and duration, while preventative vaccines have high efficacy.
- The article aims to guide healthcare providers in recognizing, diagnosing, and managing herpes zoster, highlighting the importance of awareness due to increased risk in the adult population following the introduction of varicella immunization in 2020.
In Vivo Formation of Adrenal Organoids in a Novel Porcine Model of Adrenocortical Cell Transplantation.
Endocrinology
July 2024
Faculty of Health and Medical Sciences, University of Adelaide, Adelaide 5005, Australia.
Recognizing the limitations of current therapies for Addison's disease, novel treatments that replicate dynamic physiologic corticosteroid secretion, under control of ACTH, are required. The aim of these experiments was to evaluate the feasibility of adrenocortical cell transplantation (ACT) in a large animal model, adapting methods successfully used for intracutaneous pancreatic islet cell transplantation, using a fully biodegradable temporizing matrix. Autologous porcine ACT was undertaken by bilateral adrenalectomy, cell isolation, culture, and intracutaneous injection into a skin site preprepared using a biodegradable temporizing matrix (BTM) foam.
View Article and Find Full Text PDFIL-27 disturbs lipid metabolism and restrains mitochondrial activity to inhibit γδ T17 cell-mediated skin inflammation.
Cell Death Dis
July 2024
Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Jinan University, Zhuhai, 519000, China.
IL-17+ γδ T cells (γδ T17) are kick-starters of inflammation due to their strict immunosurveillance of xenobiotics or cellular damages and rapid response to pro-inflammatory stimulators. IL-27 is a well-recognized pleiotropic immune regulator with potent inhibitory effects on type 17 immune responses. However, its actions on γδ T17 mediated inflammation and the underlying mechanisms are less well understood.
View Article and Find Full Text PDFCutibacterium acnes induces acne-like lesions in hairless mice models - A comparative study.
J Pharmacol Toxicol Methods
July 2024
Department of Pharmaceutical Technology, Unit of Dermatopharmacology, Faculty of Pharmacy, School of Health Sciences, National & Kapodistrian University of Athens, Greece. Electronic address:
Article Synopsis
- Acne vulgaris is a common inflammatory skin condition that requires reliable animal models for research on its causes and treatment options.
- This study tests different hairless mouse strains to find the best model for studying acne, focusing on the effects of Cutibacterium acnes injections.
- The SKH-hr1 mouse strain proved to be the most effective model, showing the best results for understanding acne and developing new therapies.
A preliminary investigation of precise visualization, localization, and resection of pelvic lymph nodes in bladder cancer by using indocyanine green fluorescence-guided approach through intracutaneous dye injection into the lower limbs and perineum.
Front Oncol
May 2024
Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, China.
Article Synopsis
- The study explored the use of indocyanine green (ICG) injection for tracking and assessing pelvic lymph nodes in bladder cancer, aiming for more accurate surgical removal.
- Mice models and 26 bladder cancer patients were used to compare the effectiveness of ICG injection directly under the skin versus through the urethra, focusing on the visibility and accuracy of lymph node detection.
- Results showed that the intracutaneous method was significantly more effective, achieving a 97.6% accuracy rate in fluorescent-labeled lymph nodes compared to 84.4% in the transurethral group, indicating a promising technique for improved surgical outcomes.
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