The present article report the results of longitudinally research, on growth children, of both sex and ages from 0 to 1 year of extrauterine life. We obtained measures that appraisal the muscular and fat tissues: upper arm and leg circumferences; muscle and fat of upper arm areas; triceps, subscapular and supra-iliac skinfolds. Moreover, we report relationship dates between weight and stature, which is a good indicator for morphological body equilibrium.
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J Clin Oncol
January 2025
Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Chinese University of China, Shatin, Hong Kong Special Administrative Region, China.
Purpose: Mobocertinib is an oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that targets exon 20 insertion (ex20ins) mutations in non-small cell lung cancer (NSCLC). This open-label, phase III trial (EXCLAIM-2: ClinicalTrials.gov identifier: NCT04129502) compared mobocertinib versus platinum-based chemotherapy as first-line treatment of ex20ins+ advanced/metastatic NSCLC.
View Article and Find Full Text PDFCodas
January 2025
Instituto de Psicologia, Serviço Social, Saúde e Comunicação Humana, Universidade Federal do Rio Grande do Sul - UFRGS - Porto Alegre (RS), Brasil.
Purpose: To ascertain whether Rapid Maxillary Expansion (RME) elicits effects on the functioning of the middle ear and air-bone gaps in children and adolescents.
Methods: Single-arm clinical trial, with data collection at four time points: before initiating Rapid Maxillary Expansion (RME) (T0), upon completion of RME (T1), three months post-RME completion (T2), and six months post-RME procedure (T3). The audiological assessment, conducted at all four time points, comprised otoscopy, pure tone and speech audiometry, tympanometry, and acoustic reflex investigation.
PLoS One
January 2025
Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea.
Objective: Cubital tunnel syndrome is a common peripheral neuropathy of the upper extremity. Anterior transposition of the ulnar nerve is an established surgical treatment option for this condition. This study aimed to introduce a novel musculofascial lengthening technique that uses only a portion of the flexor-pronator muscle mass for submuscular anterior transposition of the ulnar nerve and investigate its clinical outcomes.
View Article and Find Full Text PDFJAMA Cardiol
January 2025
Ifakara Health Institute, Ifakara Branch, Ifakara, United Republic of Tanzania.
Importance: Hypertension is the primary cardiovascular risk factor in Africa. Recently revised World Health Organization guidelines recommend starting antihypertensive dual therapy; clinical efficacy and tolerability of low-dose triple combination remain unclear.
Objectives: To compare the effect of 3 treatment strategies on blood pressure control among persons with untreated hypertension in Africa.
mBio
January 2025
Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA.
The 55-carbon isoprenoid, undecaprenyl-phosphate (UndP), is a universal carrier lipid that ferries most glycans and glycopolymers across the cytoplasmic membrane in bacteria. In addition to peptidoglycan precursors, UndP transports O-antigen, capsule, wall teichoic acids, and sugar modifications. How this shared but limited lipid is distributed among competing pathways is just beginning to be elucidated.
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