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The double-edged sword role of natural Killer cells in Parkinson's disease.
Cell Immunol
January 2025
Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. Electronic address:
Neurological disorders are the leading cause of disability worldwide, with Parkinson's disease (PD) emerging as a rapidly growing neurological condition on a global scale. Although treatments exist to alleviate symptoms and maintain patients' quality of life, PD remains incurable. According to some recent studies, natural killer (NK) cells may play a role in clearing alpha-synuclein aggregates, which are the main component of Lewy bodies that cause neuronal degeneration in Parkinson's disease.
View Article and Find Full Text PDF[Expert consensus on visualized tele-round and quality control management based on the improvement of clinical practice ability].
Zhonghua Nei Ke Za Zhi
February 2025
Department of Critical Care Medicine, the First Hospital of Tsinghua University, Beijing100016, China.
Turning to critical illness is a common stage of various diseases and injuries before death. Patients usually have complex health conditions, while the treatment process involves a wide range of content, along with high requirements for doctor's professionalism and multi-specialty teamwork, as well as a great demand for time-sensitive treatments. However, this is not matched with critical care professionals and the current state of medical care in China.
View Article and Find Full Text PDFTreatment Options for Nosocomial Ventriculitis/Meningitis: A Case Report and Review of the Literature.
Pathogens
December 2024
Intensive Care Unit, Department of Anesthesiology and Critical Care, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Ventriculo-meningitis or nosocomial meningitis/ventriculitis is a severe nosocomial infection that is associated with devastating neurological sequelae. The cerebrospinal fluid isolates associated with the infection can be Gram-positive or -negative, while the spp. is rarely identified.
View Article and Find Full Text PDFRetrospective Single-Center Analysis of 5575 Spinal Surgeries for Complication Associations and Potential Future Use of Generated Data.
J Clin Med
January 2025
Department of Neurosurgery, University of Luebeck, 23562 Luebeck, Germany.
: This study aims to retrospectively detect associations with postoperative complications in spinal surgeries during the hospitalization period using standardized, single-center data to validate a method for complication detection and discuss the potential future use of generated data. : Data were generated in 2006-2019 from a standardized, weekly complications conference reviewing all neurosurgical operations at the University Hospital Luebeck. Paper-based data were recorded in a standardized manner during the conference and transferred with a time delay of one week into a proprietary complication register.
View Article and Find Full Text PDFDecoding Codon Bias: The Role of tRNA Modifications in Tissue-Specific Translation.
Int J Mol Sci
January 2025
Department of Neurosurgical Engineering and Translational Neuroscience, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.
The tRNA epitranscriptome has been recognized as an important player in mRNA translation regulation. Our knowledge of the role of the tRNA epitranscriptome in fine-tuning translation via codon decoding at tissue or cell levels remains incomplete. We analyzed tRNA expression and modifications as well as codon optimality across seven mouse tissues.
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