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Alternative splicing of modulatory immune receptors in T lymphocytes: a newly identified and targetable mechanism for anticancer immunotherapy.
Front Immunol
January 2025
The Lautenberg Center for Immunology and Cancer Research, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Alternative splicing (AS) is a mechanism that generates translational diversity within a genome. Equally important is the dynamic adaptability of the splicing machinery, which can give preference to one isoform over others encoded by a single gene. These isoform preferences change in response to the cell's state and function.
View Article and Find Full Text PDFDietary patterns related to triglyceride glucose index and risk of type 2 diabetes: a large-scale cohort study.
Front Nutr
January 2025
Department of Nutrition and Food Hygiene, School of Public Health, Nantong University, Nantong, China.
Background: Triglyceride glucose (TyG) index has been proposed as a credible and simple surrogate indicator for insulin resistance. The primary aim of this study was to novelly examine the associations between dietary patterns reflecting variations in circulating TyG index and the risk of type 2 diabetes mellitus (T2DM).
Methods: This study included 120,988 participants from the UK Biobank, all of whom completed multiple 24-h dietary assessments.
Hydrothermal carbonization (HTC) of carbohydrates has been reported as a sustainable and green technique to produce carbonaceous micro- and nano-materials. These materials have been developed for several applications, including catalysis, separation science, metal ion adsorption and nanomedicine. Carbon nanoparticles (CNPs) obtained through HTC are particularly interesting for the latter application since they exhibit photothermal properties when irradiated with near-infrared (NIR) light, act as an antioxidant by scavenging reactive oxygen species (ROS), and present good colloidal stability and biocompatibility.
View Article and Find Full Text PDFThe mitochondria as a potential therapeutic target in cerebral I/R injury.
Front Neurosci
January 2025
Department of Neurology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.
Ischemic stroke is a major cause of mortality and disability worldwide. Among patients with ischemic stroke, the primary treatment goal is to reduce acute cerebral ischemic injury and limit the infarct size in a timely manner by ensuring effective cerebral reperfusion through the administration of either intravenous thrombolysis or endovascular therapy. However, reperfusion can induce neuronal death, known as cerebral reperfusion injury, for which effective therapies are lacking.
View Article and Find Full Text PDFExternal Validation of the Walter Index for Posthospitalization Mortality Prediction in Older Adults.
JAMA Netw Open
January 2025
Division of Geriatrics, School of Medicine, University of California San Francisco.
Importance: The Walter Index is a widely used prognostic tool for assessing 12-month mortality risk among hospitalized older adults. Developed in the US in 2001, its accuracy in contemporary non-US contexts is unclear.
Objective: To evaluate the external validity of the Walter Index in predicting posthospitalization mortality risk in Brazilian older adult inpatients.
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