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High Glucose Causes Distinct Expression Patterns of Primary Human Skin Cells by RNA Sequencing.
Front Endocrinol (Lausanne)
January 2022
Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Diabetes-related skin problems represent the most common long-term complications in diabetes mellitus patients. These complications, which include diabetic dermopathy, diabetic blisters, necrobiosis lipoidica diabeticorum, and eruptive xanthomatosis, may dramatically impair patients' quality of life and cause long-lasting disability. However, the cellular and molecular mechanisms linking diabetes-related hyperglycemia and skin complications are still incompletely understood.
View Article and Find Full Text PDFNecrobiotic xanthogranuloma associated with necrotizing scleritis.
Am J Dermatopathol
August 2012
Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.
A 57-year-old man presented to the ophthalmology clinic with a red right eye. He denied pain, diplopia, tearing, and blurred vision. His medical history included asymptomatic annular plaques on the trunk and extremities for at least a decade.
View Article and Find Full Text PDFNecrobiotic xanthogranuloma with paraproteinemia.
Cutis
May 1996
Department of Dermatology, Sheba Medical Center, Tel Hashomer, Israel.
Necrobiotic xanthogranuloma (NXG) is a rare skin disease mimicking necrobiosis lipoidica diabeticorum clinically and histologically. However, its association with paraproteinemia, and the evolution of hematologic malignancies in some cases, established NXG as a separate clinicopathologic entity. A typical case with indolent course is described.
View Article and Find Full Text PDFNecrobiotic xanthogranuloma: a case without paraproteinemia but with transepithelial elimination.
J Cutan Pathol
April 1988
Dermatology Service, Purpan Hôpital, Toulouse, France.
We report a female patient, now aged 60, followed for 20 years for lesions originally diagnosed as necrobiosis lipoidica diabeticorum. In fact, the anatomical and clinical features of her disorder correspond to the new entity described as necrobiotic xanthogranuloma. Two elements distinguish this from earlier cases: 1) two examinations failed to reveal paraproteinemia; 2) there was transepithelial elimination of cholesterol crystals and degenerated xanthomatous cell debris via hair follicles.
View Article and Find Full Text PDFNecrobiosis lipoidica diabeticorum with cholesterol clefts in the differential diagnosis of necrobiotic xanthogranuloma.
J Cutan Pathol
February 1988
Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
The histopathologic findings in 331 cases of necrobiosis lipoidica diabeticorum seen during a 50-year period were reviewed. Three cases showing cholesterol cleft formation were found. All 3 cases were associated with severe diabetes mellitus.
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