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Quality of Life and Adaptation of People With a Colostomy Plug: A Before-After Interventional Study.
J Wound Ostomy Continence Nurs
January 2025
Iraktânia Vitorino Diniz, MSc, RN, Doctoral Student in Nursing at the Federal University of Paraiba, Campus I - Lot. City Universitaria, João Pessoa, Paraíba 58051-900, Brazil.
Purpose: The purpose of this study was to examine health-related quality of life and adaptation of persons with a colostomy before and after use of a colostomy plug.
Design: Single group before-and-after study.
Subjects And Setting: The study sample comprised 19 people with a colostomy who attended an outpatient clinic João Pessoa, in Paraiba, Brazil.
Can a Cochlear Implant Be Used as an Electrical Impedance Tomography Device?
Int J Numer Method Biomed Eng
January 2025
Bioengineering, Department of Electrical, Electronic and Computer Engineering, University of Pretoria, Gauteng, South Africa.
The imaging of the live cochlea is a challenging task. Regardless of the quality of images obtained from modern clinical imaging techniques, the internal structures of the cochlea mainly remain obscured. Electrical impedance tomography (EIT) is a safe, low-cost alternative medical imaging technique with applications in various clinical scenarios.
View Article and Find Full Text PDFThe impact of genetic variability on Alzheimer's therapies: obstacles for pharmacogenetic progress.
Expert Opin Drug Metab Toxicol
January 2025
EuroEspes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, Bergondo, Corunna, Spain.
Introduction: Genetic load influences the therapeutic response to conventional drugs in Alzheimer's disease (AD). Pharmacogenetics (PGx) is the best option to reduce drug-drug interactions and adverse drug reactions in patients undergoing polypharmacy regimens. However, there are important limitations that make it difficult to incorporate pharmacogenetics into routine clinical practice.
View Article and Find Full Text PDFEarly detection and management of hearing loss to reduce dementia risk in older adults with mild cognitive impairment: findings from the treating auditory impairment and cognition trial (TACT).
Age Ageing
January 2025
Division of Psychiatry, University College London, London, UK.
Background: Age-related hearing loss and mild cognitive impairment (MCI) independently increase dementia risk. The Ageing and Cognitive Health Evaluation in Elders randomised controlled trial (RCT) found hearing aids reduce cognitive decline in high-risk older adults with poor hearing.
Methods: This pilot RCT in London memory clinics randomised people with MCI (aged ≥55, untreated hearing loss defined as Pure Tone Average 0.
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