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Impaired HDL Cholesterol Function and High Interleukin-1ß Levels Hold Prognostic Value after ST-elevation Myocardial Infarction.
Eur J Prev Cardiol
January 2025
Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
When Is Enough Enough? Additional Evidence of the Power of Zero.
Circ Cardiovasc Imaging
January 2025
Department of Medicine, Lundquist Institute at Harbor-UCLA, Torrance, CA, USA.
Tools to Score and Predict Cholesterol-Protein Interactions.
J Med Chem
December 2024
Department of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois 60607, United States.
Cholesterol is structurally distinct from other lipids, which confers it with singular roles in membrane organization and protein function. As a signaling molecule, cholesterol engages in discrete interactions with transmembrane, peripheral, and certain soluble proteins to control cellular responses. Accordingly, the cholesterol-protein interface is central to cholesterol-related diseases and is an essential consideration in drug design.
View Article and Find Full Text PDFSR-BI Models for Spontaneous Myocardial Infarction: High Unesterified/Total Cholesterol Ratio Not the Sole Piece of the Puzzle.
Arterioscler Thromb Vasc Biol
December 2024
Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, the Netherlands. Pharmacy Leiden, the Netherlands.
Prevention and Management of Cardiovascular Disease in Primary Care: A Comment on the PEER Simplified Lipid Guideline.
CJC Open
October 2024
Crowfoot Village Family Practice, Calgary, Alberta, Canada.
Background: In Canada, 2 guidelines provide guidance for the management of dyslipidemia. The Patients, Experience, Evidence, Research simplified lipid guidelines, intended for primary care practitioners, and the Canadian Cardiovascular Society guidelines, intended for all practitioners, are based on differing methodologies with distinct priorities and preferences. The disparate approaches may contribute to confusion among family practitioners and their co-managed patients, with the potential for compromised care, differing standards for training in the fundamentals of lipidology, and differing criteria that might be used in practice audits to evaluate quality of care.
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