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Extraction of premolars in orthodontic treatment does not negatively affect upper airway volume and minimum cross-sectional area: a systematic review with meta-analysis.
Eur J Orthod
February 2025
Division of Orthodontics, University Clinics of Dental Medicine, Faculty of Medicine, University of Geneva, Rue Miche-Servet 1, 1211 Geneva, Switzerland.
Background: Extraction of premolars is usually prescribed for the orthodontic treatment of cases with inadequate space within the dental arch or when anterior teeth retraction is indicated; however, it has been advocated that this treatment approach could negatively influence the airways.
Objective: To identify and critically appraise studies of premolar extractions during orthodontic treatment on upper airway dimensions. Search methods: Electronic unrestricted searches in nine databases until October 2024.
Survival analysis of patients with metastatic head and neck squamous cell carcinoma treated with metastasis-directed radiotherapy and immunotherapy.
Radiat Oncol
March 2025
Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Objective: Immunotherapy combined with chemotherapy is currently the first-line treatment for metastatic head and neck squamous cell carcinoma (HNSCC). This study aims to evaluate whether adding metastasis-directed radiotherapy (MDRT) to immunotherapy and chemotherapy could improve the survival rate of patients with metastatic HNSCC.
Materials And Methods: A retrospective analysis was conducted on patients with HNSCC who developed distant metastases after curative treatment.
Select Airway Specialized Pro-Resolving Mediators Are Associated with Recovery from Non-Viral COPD Exacerbations.
Am J Respir Crit Care Med
March 2025
Imperial College London National Heart and Lung Institute, National Heart and Lung Institute, London, United Kingdom of Great Britain and Northern Ireland.
Rationale: Recovery from chronic obstructive pulmonary disease (COPD) exacerbations is heterogeneous and has a profound impact on disease trajectories. Resolution of airway inflammation is an active process which may be driven by Specialized Pro-resolving Mediators (SPMs).
Objectives: To characterize the temporal change in SPMs in the sputum of COPD patients during COPD exacerbations, their association with exacerbation triggers and exacerbation recovery.
Five challenging presentations of juvenile nasopharyngeal angiofibroma: our experience in the diagnosis and endoscopic surgical management.
J Surg Case Rep
February 2025
Department of Otolaryngology-Head and Neck Surgery, King Fahad Specialist Hospital, Dammam, Saudi Arabia.
Juvenile nasopharyngeal angiofibroma (JNA) is a benign tumor originating from the pterygopalatine fossa and is the most common lesion of the nasopharynx. Its hypervascularity and complex anatomical extensions make selecting the most effective surgical approach intricate. All patients in this series were males, and their age ranged between 8 and 23 years.
View Article and Find Full Text PDFEstimating the serotype-specific association between the concentration of vaccine-induced serum antibodies and protection against pneumococcal colonization.
J Infect Dis
February 2025
Public Health Modeling Unit, Yale School of Public Health, New Haven, CT, USA.
Background: Pneumococcal conjugate vaccines (PCVs) offer indirect protection by reducing pneumococcal colonization in the vaccinated children and thus transmission. As higher-valency PCVs may trigger a weaker immune response, it is important to understand how differences in immunogenicity between PCVs translate to effectiveness against colonization.
Methods: We estimated the serotype-specific relationship between the concentration of vaccine-induced serum immunoglobulin G (IgG) and protection against colonization using a hierarchical Bayesian model with the longitudinal data from a randomized controlled trial in Israel.
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