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Functional reconstruction following bilateral amputation of the manus and pes in a cat with frostbite injury.
Can Vet J
January 2025
Guardian Veterinary Centre, 5620 99th Street NW, Edmonton, Alberta T6E 1V2 (Cormillot); VCA Canada, Guardian Veterinary Centre, 5620 99th Street NW, Edmonton, Alberta T6E 1V2 (Fowler).
This case report describes metacarpophalangeal (MCP)- and metatarsophalangeal (MTP)-level amputation and reconstruction of all 4 paws of a young female domestic shorthair cat. All 4 paws, the ears, and the distal portion of the tail underwent severe frostbite injury resulting in tissue death. Following MCP and MTP amputation, weight-bearing surface reconstruction was achieved using metacarpal and metatarsal paw-pad advancement flaps.
View Article and Find Full Text PDFIn situ forming Hydrogel with adding ZnO Nano-particle for effectively methicillin-resistant Staphylococcus aureus infected frostbite injury.
Regen Ther
June 2024
The Third Affiliated Hospital of Anhui Medical University, Hefei's First People's Hospital, Anhui Medical University, Hefei, Anhui 230000, People's Republic of China.
Unlabelled: Hydrogel has emerged as a promising wound dressing material, and in situ forming hydrogel has emerged as a promising wound dressing recently. But most in situ forming hydrogel are normally unstable. Herein, we report an in-situ forming hydrogel synthesized from poly(Nisopropylacrylamide166---butyl acrylate9)-poly(ethyleneglycol)-poly(N-isopropylacrylamide166---butyl acrylate9) copolymer (P(NIPAM166--nBA9)-PEG-P(NIPAM166-conBA9), denoted as PEP) and zinc oxide nano-particle(ZnO nano-particle) in response to skin temperature.
View Article and Find Full Text PDFCold Injury.
Emerg Med Clin North Am
August 2024
Department of Emergency Medicine, Alaska Regional Hospital, Anchorage, AK, USA; National Park Service, Alaska Region. Electronic address:
Article Synopsis
- Cold injuries, particularly frostbite, have been a documented issue for a long time, affecting military personnel, winter sports enthusiasts, and homeless individuals in urban areas.
- Recent treatment improvements include thrombolytic and prostaglandin therapies, but the primary approach is still quick identification and rewarming of the affected area.
- The chapter specifically emphasizes frostbite while also briefly touching on other related cold injuries.
Elucidation of the Role of TRPV1, VEGF-A, TXA2, Redox Homeostasis, and Inflammatory Cascades in Protection against Cold Injuries by Herbosomal-Loaded PEG-Poloxamer Topical Formulation.
ACS Appl Bio Mater
May 2024
Disruptive and Deterrence Technologies Division, Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization, Lucknow Road, Timarpur, New Delhi 110054, India.
High-altitude regions, cold deserts, permafrost regions, and the polar region have some of the severest cold conditions on earth and pose immense perils of cold injuries to exposed individuals. Accidental and unintended exposures to severe cold, either unintentionally or due to occupational risks, can greatly increase the risk of serious conditions including hypothermia, trench foot, and cold injuries like frostbite. Cold-induced vasoconstriction and intracellular/intravascular ice crystal formation lead to hypoxic conditions at the cellular level.
View Article and Find Full Text PDFThe Assessment of a Novel Endoscopic Ultrasound-Compatible Cryocatheter to Ablate Pancreatic Cancer.
Biomedicines
February 2024
CPSI Biotech, Owego, NY 13827, USA.
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease that may be treated utilizing thermal therapies. Cryoablation is an effective, minimally invasive therapy that has been utilized for the treatment of various cancers, offering patients a quicker recovery and reduced side effects. Cryoablation has been utilized on a limited basis for the treatment of PDAC.
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