In an experimental design with two matched groups (n = 13 and n = 17) working 2 and 4 hr respectively, followed by a 15-min restitution time, the study examined the effect of continuous VDT work on 1) visual acuity, refraction and oculomotor functions (ZCSV: zone of clear, single vision) and 2) the effect of 15-min restitution time on the oculomotor functions (ZCSV). In both groups there were a significant reduction in visual acuity, refraction changes in myopic direction and reduced ciliar and vergence muscle capacity. The ZCSV changes were temporary and a 15-min restitution period restored approximately half of the ZCSV changes. There were no significant differences between 2 or 4 hr of VDT work on any of the variables examined.
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Front Physiol
April 2020
Anesthesia and Critical Care Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
Aims: Complete restitution of neurologic function after 6 h of pre-hospital resuscitation and in-hospital rewarming has been reported in accidental hypothermia patients with cardiac arrest (CA). However, the level of restitution of circulatory function during long-lasting hypothermic cardiopulmonary resuscitation (CPR) remains largely unknown. We compared the effects of CPR in replacing spontaneous circulation during 3 h at 27°C vs.
View Article and Find Full Text PDFNeuropharmacology
April 2017
Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland; Irish Centre for Fetal and Neonatal Translational Research (INFANT) Cork, Ireland. Electronic address:
Neonatal seizures are a common consequence of hypoxic/ischemic encephalopathy (HIE). Phenobarbital remains the frontline treatment for neonatal seizures but is often ineffective. The P2X7 receptor (P2X7R) is a cell surface-expressed ionotropic receptor activated by high amounts of ATP which may be released during seizures or as a consequence of tissue injury.
View Article and Find Full Text PDFNeurobiol Dis
November 2015
Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland; Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork, Ireland. Electronic address:
Seizures are common during the neonatal period, often due to hypoxic-ischemic encephalopathy and may contribute to acute brain injury and the subsequent development of cognitive deficits and childhood epilepsy. Here we explored short- and long-term consequences of neonatal hypoxia-induced seizures in 7 day old C57BL/6J mice. Seizure activity, molecular markers of hypoxia and histological injury were investigated acutely after hypoxia and response to chemoconvulsants and animal behaviour was explored at adulthood.
View Article and Find Full Text PDFBiomed Res Int
November 2015
Division of Cardiology, Department of Medicine, Chang Gung Memorial Hospital, Linkou District, Taiwan ; Chang Gung University College of Medicine, Taoyuan City, Taiwan.
Dantrolene was reported to suppress ventricular fibrillation (VF) in failing hearts with acute myocardial infarction, but its antiarrhythmic efficacy in regional ischemia-reperfusion (IR) hearts remains debatable. Heart failure (HF) was induced by right ventricular pacing. The IR rabbit model was created by coronary artery ligation for 30 min, followed by reperfusion for 15 min in vivo in both HF and non-HF groups (n = 9 in each group).
View Article and Find Full Text PDFInt J Cardiol
February 2014
Division of Cardiology, Department of Medicine, Chang Gung Memorial Hospital, Linko, Taiwan.
Background: Piceatannol, a hydroxystilbene natural product, has been reported to exert antiarrhythmic action via INa inhibition and slow INa inactivation in ischemia-reperfused (IR) rat hearts. The present study aimed to clarify the proarrhythmic property of piceatannol during regional IR injury in failing rabbit hearts.
Methods: Heart failure (HF) was induced by rapid right ventricular pacing for 4 weeks.
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