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| http://dx.doi.org/10.1136/pgmj.28.316.107 | DOI Listing |
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A strain lacking the iron transport system is virulent in human volunteers.
Infect Immun
June 2024
Department of Microbiology and Immunology, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana, USA.
Article Synopsis
- Chancroid, a genital ulcer disease causing painful skin ulcers, is linked to a bacterium that uses a specific receptor, HgbA, to acquire heme from hosts, crucial for its disease progression.
- The study involved creating a mutant strain (35000HPΔΔ) that showed growth issues when using human hemoglobin for iron; however, trials with human volunteers showed both the mutant and the parent strain produced similar skin reactions, indicating that the YfeABCD transporter isn't essential for the bacteria's virulence.
- The research suggests that despite the deletion of the YfeABCD system, the bacteria can rely on alternative transport systems like HbpA and others to manage heme transport, highlighting the redundancy of vir
Prevalence and risk factors associated with Haemophilus ducreyi cutaneous ulcers in Cameroon.
PLoS Negl Trop Dis
December 2023
Centre Pasteur du Cameroun, Yaounde, Cameroon.
Article Synopsis
- * Conducted in Cameroon, the research included 443 participants, revealing a 30.3% prevalence of HD in ulcers and 8.6% in asymptomatic individuals, while Treponema pallidum (TP) was found at a lower rate of 5.2%.
- * Risk factors included gender parity in HD ulcer cases and physical proximity to confirmed cases, with findings indicating that HD is the most common cause of skin ulcers in the studied areas, warranting further research into asymptomatic carriage and disease transmission. *
Dispensability of Ascorbic Acid Uptake and Utilization Encoded by ulaABCD for the Virulence of Haemophilus ducreyi in Humans.
J Infect Dis
February 2023
Departments of Microbiology and Immunology, Indiana University, Indianapolis, Indiana, USA.
Compared with wounded skin, ascorbic acid is enriched in pustules of humans experimentally infected with Haemophilus ducreyi. Compared with the broth-grown inocula, transcription of the H. ducreyi ulaABCD operon, which encodes genes for ascorbic acid uptake, is increased in pustules.
View Article and Find Full Text PDFGenes Differentially Expressed by Haemophilus ducreyi during Anaerobic Growth Significantly Overlap Those Differentially Expressed during Experimental Infection of Human Volunteers.
J Bacteriol
May 2022
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Haemophilus ducreyi causes cutaneous ulcers in children and the genital ulcer disease chancroid in adults. In humans, H. ducreyi is found in the anaerobic environment of an abscess; previous studies comparing bacterial gene expression levels in pustules with the inocula (∼4-h aerobic mid-log-phase cultures) identified several upregulated differentially expressed genes (DEGs) that are associated with anaerobic metabolism.
View Article and Find Full Text PDFInteractions of the Skin Pathogen With the Human Host.
Front Immunol
June 2021
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States.
The obligate human pathogen causes both cutaneous ulcers in children and sexually transmitted genital ulcers (chancroid) in adults. Pathogenesis is dependent on avoiding phagocytosis and exploiting the suppurative granuloma-like niche, which contains a myriad of innate immune cells and memory T cells. Despite this immune infiltrate, long-lived immune protection does not develop against repeated infections-even with the same strain.
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