Problems in performing a double-blind multicenter study using a hypnotic in private practice.

Int J Clin Pharmacol Ther Toxicol

Rhône-Poulenc Rorer GmbH, Cologne, Germany.

Published: November 1992

1. The procedure described--the immediate data transfer and entry system (ITES)--is suitable to improve the quality of data collected in multicentre studies in private practice. 2. The results of the study show that regarding influence on sleep quality and daytime well-being the non-benzodiazepine Z is significantly superior to placebo and slightly superior to the benzodiazepines F and T. 3. The advantage of Z treatment is the better daytime well-being after taking the hypnotic for sleep induction the night before. 4. This study shows that a quality standard equal to that in clinical practice may be achieved in private practice.

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