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Reducing the Formation of Toxic Byproducts During the Photochemical Release of Epinephrine.
J Xenobiot
January 2025
Department of Physics, Novosibirsk State University, 630090 Novosibirsk, Russia.
Engineered light-sensitive molecules offer a sophisticated toolkit for the manipulation of biological systems with both spatial and temporal precision. Notably, artificial "caged" compounds can activate specific receptors solely in response to light exposure. However, the uncaging process can lead to the formation of potentially harmful byproducts.
View Article and Find Full Text PDFTowards a Quantitative Description of Proteolysis: Contribution of Demasking and Hydrolysis Steps to Proteolysis Kinetics of Milk Proteins.
Foods
January 2025
A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, Moscow 119991, Russia.
The hydrolysis of proteins by proteases (proteolysis) plays a significant role in biology and food science. Despite the importance of proteolysis, a universal quantitative model of this phenomenon has not yet been created. This review considers approaches to modeling proteolysis in a batch reactor that take into account differences in the hydrolysis of the individual peptide bonds, as well as the limited accessibility (masking) for the enzymes of some hydrolysis sites in the protein substrate.
View Article and Find Full Text PDFPrototype of Implant for Nitric Oxide Release Controlled by Infrared Radiation in Therapeutic Window.
J Biophotonics
December 2024
Novosibirsk State University, Novosibirsk, Russia.
Local therapeutic action and targeted drug release are promising approaches compared to traditional systemic drug administration. This is especially relevant for nitric oxide (NO), as its effects change dramatically depending on concentration and cellular context. Materials capable of releasing NO in deep tissues in a controlled manner might open new therapeutic opportunities.
View Article and Find Full Text PDFAdrenochrome formation during photochemical decomposition of "caged" epinephrine derivatives.
Photochem Photobiol Sci
December 2024
Novosibirsk State University, Novosibirsk, Russia.
Control of biological activity with light is a fascinating idea. "Caged" compounds, molecules modified with photolabile protecting group, are one of the instruments for this purpose. Adrenergic receptors are essential regulators of neuronal, endocrine, cardiovascular, vegetative, and metabolic functions.
View Article and Find Full Text PDFExactly Solvable Anharmonic Oscillator, Degenerate Orthogonal Polynomials and Painlevé II.
Commun Math Phys
February 2024
SISSA, International School for Advanced Studies, via Bonomea 265, Trieste, Italy.
Using WKB analysis, the paper addresses a conjecture of Shapiro and Tater on the similarity between two sets of points in the complex plane; on one side is the set the values of for which the spectrum of the quartic anharmonic oscillator in the complex plane with certain boundary conditions, has repeated eigenvalues. On the other side is the set of zeroes of the Vorob'ev-Yablonskii polynomials, i.e.
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