Between 1976 and 1990, we treated 56 isthmic spondylolisthesis patients with an average age of 15 + 4 (range, 4 + 9 to 27 +/- 2) with in situ bilateral transverse process fusions utilizing autogenous iliac bone graft. None of the patients had a decompression or instrumentation placed. Radiographic fusion was determined from standing spot lateral radiographs and either Ferguson AP or standing AP views of the lumbosacral junction. The radiographic fusion patterns were categorized into the following four grades: (A) definitely solid (n = 28, 50%)--solid big trabeculated bilateral fusion masses; (B) possibly solid (n = 10, 18%)--unilateral large fusion mass with contralateral small fusion mass; (C) probably not solid (n = 6, 11%)--small, thin fusion masses bilaterally; (D) definitely not solid (n = 12, 21%)--graft resorption bilaterally or fusion mass with obvious bilateral pseudarthrosis. This fusion pattern is best determined by the Ferguson ("true AP") radiograph of the lumbosacral junction. Despite this surprisingly low fusion rate, overall clinical improvement was noted in > 80% of patients with preoperative symptoms of back pain, leg pain, or hamstring tightness. We recommend this critical assessment of fusion grades to determine fusion success in this patient population.
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JBJS Case Connect
January 2025
Department of Orthopaedics, Mass General Brigham, Boston, Massachusetts.
Case: A 51-year-old male polytrauma patient presented with bilateral calcaneus fractures after a fall. This report describes treatment of his right comminuted Sanders IV calcaneus fracture with percutaneous open reduction internal fixation (ORIF) and minimally invasive surgery (MIS) primary subtalar fusion to restore alignment and preserve soft tissue.
Conclusion: Unlike traditional open approaches, which are prone to wound complications due to larger incisions, our approach of maintaining fracture alignment during joint preparation using an MIS burr for acute posttrauma subtalar arthrodesis and percutaneous ORIF appears to have reduced these risks, resulting in successful radiological healing and functional recovery at 1-year follow-up.
Case: A 60-year-old right-hand-dominant woman experienced progressive enlargement of a mass over the index distal interphalangeal (DIP) joint over 5 years, leading to joint destruction and swan neck deformity. Radiography showed arthritis, erosion, and calcific deposition. Surgical intervention included mass excision, synovectomy, and DIP joint arthrodesis.
View Article and Find Full Text PDFRev Sci Instrum
January 2025
Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang 621900, China.
In inertial confinement fusion experiments, hot spot mix caused by hydrodynamic instabilities is a critical performance limitation. Currently, multi-channel Ross filter pair imaging is used to quantitatively diagnose the mix mass of cryogenic hot spots driven by 100 kJ energy, but this method brings significant uncertainty. To measure the level of mix more accurately, we have developed a two-temperature model to modify the fitted bremsstrahlung spectra based on the characteristics of cryogenic implosion hot spots.
View Article and Find Full Text PDFCurr Issues Mol Biol
January 2025
Department of Biopharmacy, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
(Mhp) infection severely affects the daily weight gain and feed-to-meat ratio of pigs, while secondary infections with other pathogens can further lead to increased mortality, causing significant economic losses to the pig industry. CD40L is a molecular adjuvant that enhances the cellular and humoral immune responses to vaccines. In this study, the CD40L peptide was fused to the C-terminus of the chimeric P97R1P46P42 protein by genetic engineering using the pFastBac Dual vector.
View Article and Find Full Text PDFClin Pract
January 2025
Department of Cardiology and Internal Medicine, Colțea Clinical Hospital, 030167 Bucharest, Romania.
The purpose of this article is to overview the clinical significance of left supraclavicular adenopathy and review the etiology of inferior vena cava (IVC) thrombosis, starting from a presentation of a rare case of renal cell carcinoma (RCCs) with Xp11.2 translocation involving TFE3 gene fusion. This article also aims to review the literature to understand the characteristics of this rare type of renal tumor.
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