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Outcome measures in muscular dystrophy rehabilitation: an ICF content comparison approach to the most commonly used MD scales.
J Rehabil Med
January 2025
WHOFIC Academic Collaborating Center- Univesitat de Barcelona, Barcelona, Spain; August Pi i Sunyer Biomedical Research Institute (IDIBAPS) University of Barcelona, Barcelona, Spain; Physical and Rehabilitation Department, Hospital Clinic, ICEMEQ, Barcelona, Spain; Clinical and Experimental Respiratory Immunoallergy (IRCE), Clinic Foundation for Biomedical Research, Barcelona, Spain.
Introduction: Functioning is the reason to be of rehabilitation as it is essential to the lives of people who suffer from a disease. The International Classification of Functioning, Disability and Health (ICF) can help in designing a functioning profile of a patient, identifying needs for rehabilitation plans and measuring the results of an intervention.
Objective: To identify the outcome measurement instruments reported in clinical studies in muscular dystrophies (MDs) and provide an ICF content analysis.
Bipyramidal gold nanoparticles-assisted plasmonic photothermal therapy for ocular applications.
J Mater Chem B
January 2025
Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Department of Ophthalmology, Reina Sofia University Hospital and University of Cordoba, 14004 Cordoba, Spain.
Gold nanoparticles (AuNPs) play a key role in the field of nanomedicine due to their fascinating plasmonic properties as well as their great biocompatibility. An intriguing application is the use of plasmonic photothermal therapy (PPTT) mediated by anisotropic AuNPs irradiated with a near-infrared (NIR) laser for treating ocular diseases in ophthalmology. For this purpose, bipyramidal-shaped AuNPs (BipyAu), which were surface-functionalized with three different organic ligands (citrate, polystyrene sulphonate (PSS), and cetyltrimethylammonium bromide (CTAB)), were synthesized.
View Article and Find Full Text PDFLate Endovascular Treatment for Ischemic Stroke with Moderate to Large Infarct Volume is Associated with a Better Clinical Prognosis.
Curr Neurovasc Res
January 2025
Center for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Objective: The concept of "time is brain" is crucial for the reperfusion therapy of ischemic stroke. However, the Infarct Growth Rate (IGR) varies among individuals, which is regarded as a more powerful factor than the time when determining infarct volume and its association with clinical outcomes. For stroke patients with a similar infarct volume, a longer time from stroke Onset to Imaging (OTI) correlates with a lower IGR, which may indicate a better prognosis.
View Article and Find Full Text PDFDeterminants of Quality of Life in Patients With Urinary Incontinence: An Assessment Using the Incontinence Quality of Life (I-QOL) Scale.
Cureus
December 2024
Department of Epidemiology, Clinical Research and Community Health, Faculty of Medicine, Pharmacy and Dentistry of Fez, Sidi Mohamed Ben Abdellah University, Fez, MAR.
Background Urinary incontinence is a significant health problem with physical, social, economic, and psychological consequences for patients and their quality of life. The aim of our study is to determine the impact of urinary incontinence on the quality of life and to identify its determinants in patients with this condition. Materials and methods A cross-sectional study was carried out in the diagnostic center of Centre Hospitalier Universitaire (CHU) Hassan II in Fez, Morocco, between June and September 2019.
View Article and Find Full Text PDFAn extracellular vesicle based hypothesis for the genesis of the polycystic kidney diseases.
Extracell Vesicle
December 2024
The Jared Grantham Kidney Institute at the University of Kansas Medical Center, Department of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Autosomal dominant polycystic kidney (ADPKD) disease is the commonest genetic cause of kidney failure (affecting 1:800 individuals) and is due to heterozygous germline mutations in either of two genes, and . Homozygous germline mutations in are responsible for autosomal recessive polycystic kidney (ARPKD) disease a rare (1:20,000) but severe neonatal disease. The products of these three genes, (polycystin-1 (PC1 4302(3)aa)), (polycystin-2 (PC2 968aa)) and (fibrocystin (4074aa)) are all present on extracellular vesicles (EVs) termed, PKD-exosome-like vesicles (PKD-ELVs).
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