[Discrepant results with immunohistochemical detection TDx/ADx?].

Beitr Gerichtl Med

Institut für Rechtsmedizin, Universität Bonn.

Published: February 1993

AI Article Synopsis

  • In a two-year period, the study encountered challenges in verifying thin-layer results for various substances using the TDx/ADx immunoassay system.
  • Out of 883 urine screenings conducted, there were 157 discrepancies, indicating a 20% error rate.
  • The research included testing the compatibility and detection limits of TDx and ADx, as well as a comparison with thin-layer chromatography, ultimately demonstrating that both systems produced reproducible results.

Article Abstract

In the last 2 years we had some problems to confirm the thin-layer results (amphetamines, opiates, benzodiazepines, barbiturates and cocaine) with the immunoassay system TDx/ADx. Between January 1989 and December 1990 we did 883 screenings in urine samples (pre- and postmortal) and had 157 discrepancies (20%). In regard of the high level of discrepancies, we had to test the compatibility of TDx and ADx, their detection limits and compared the results with a second method, thin-layer chromatography. Determining the correlation coefficients to prove our results statistically, we found that both systems, TDx and ADx, work reproducible.

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